P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach
Rationale and Aim: This study is aimed at identifying possible patterns of vascular wall disarray and remodeling in radial arteries of patients with fibromuscular dysplasia (FMD), by means of ultrahigh frequency ultrasound (UHFUS). Methods: UHFUS scans of the radial arteries and of 30 FMD patients...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-12-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125950093/view |
| _version_ | 1818538123232018432 |
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| author | Federica Poli Rosa Maria Bruno Francesco Faita Hakim Khettab Michel Azizi Saverio Vitali Mirco Cosottini Davide Caramella Lorenzo Ghiadoni Stefano Taddei Pierre Boutouyrie Alexandre Persu Xavier Jeunemaitre Aurélien Lorthioir |
| author_facet | Federica Poli Rosa Maria Bruno Francesco Faita Hakim Khettab Michel Azizi Saverio Vitali Mirco Cosottini Davide Caramella Lorenzo Ghiadoni Stefano Taddei Pierre Boutouyrie Alexandre Persu Xavier Jeunemaitre Aurélien Lorthioir |
| author_sort | Federica Poli |
| collection | DOAJ |
| description | Rationale and Aim: This study is aimed at identifying possible patterns of vascular wall disarray and remodeling in radial arteries of patients with fibromuscular dysplasia (FMD), by means of ultrahigh frequency ultrasound (UHFUS).
Methods: UHFUS scans of the radial arteries and of 30 FMD patients and 30 healthy controls were obtained by VevoMD (70 MHz probe, FUJIFILM, VisualSonics, Toronto, Canada). 10 end-diastolic frames for each subject were analyzed. 74 radiomic features and 4 engineered parameters were extracted: intima-media thickness (IMT) and adventitia thickness (AT), an adjunctive acoustic interface for each layer (IMT and AT triple signal). The extracted parameters were used to train classification models, using Support Vector Machine Linear (SVM), K-Nearest Neighbors (KNN), Logistic Regression, Linear Discriminant Analysis (LDA). The models were then tested on an independent validation population (38 FMD patients and 28 healthy subjects).
Results: IMT (185 ± 46 vs 168 ± 37, p =) and AT (104 ± 34 vs 96 ± 35, p = 0.004) were significantly higher in FMD than in controls. IMT and AT triple signal were also more frequent in FMD than in control images (p < for both). The most accurate classification models were LDA (sensitivity = 0.67, specificity = 0.76, accuracy = 0.71, AUC = 0.71) and Logistic Regression (sensitivity = 0.71, specificity = 0.72, accuracy = 0.71, AUC = 0.71). The models showed and accuracy of about 70% when tested on the validation population.
Conclusions: Wall ultrastructure of radial arteries of FMD patients is extensively altered: IMT and AT are thickened and the first and/or second layer of the arterial wall is splitted, showing a triple signal feature. Radiomic descriptors combined with engineered parameters allow to distinguish between radial images from FMD patients and controls with a 70% accuracy. |
| first_indexed | 2024-12-11T21:24:57Z |
| format | Article |
| id | doaj.art-8def0ce27b0142fa9403bb2dceea48c6 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-11T21:24:57Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-8def0ce27b0142fa9403bb2dceea48c62022-12-22T00:50:21ZengBMCArtery Research1876-44012020-12-0126Supplement 110.2991/artres.k.201209.062P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic ApproachFederica PoliRosa Maria BrunoFrancesco FaitaHakim KhettabMichel AziziSaverio VitaliMirco CosottiniDavide CaramellaLorenzo GhiadoniStefano TaddeiPierre BoutouyrieAlexandre PersuXavier JeunemaitreAurélien LorthioirRationale and Aim: This study is aimed at identifying possible patterns of vascular wall disarray and remodeling in radial arteries of patients with fibromuscular dysplasia (FMD), by means of ultrahigh frequency ultrasound (UHFUS). Methods: UHFUS scans of the radial arteries and of 30 FMD patients and 30 healthy controls were obtained by VevoMD (70 MHz probe, FUJIFILM, VisualSonics, Toronto, Canada). 10 end-diastolic frames for each subject were analyzed. 74 radiomic features and 4 engineered parameters were extracted: intima-media thickness (IMT) and adventitia thickness (AT), an adjunctive acoustic interface for each layer (IMT and AT triple signal). The extracted parameters were used to train classification models, using Support Vector Machine Linear (SVM), K-Nearest Neighbors (KNN), Logistic Regression, Linear Discriminant Analysis (LDA). The models were then tested on an independent validation population (38 FMD patients and 28 healthy subjects). Results: IMT (185 ± 46 vs 168 ± 37, p =) and AT (104 ± 34 vs 96 ± 35, p = 0.004) were significantly higher in FMD than in controls. IMT and AT triple signal were also more frequent in FMD than in control images (p < for both). The most accurate classification models were LDA (sensitivity = 0.67, specificity = 0.76, accuracy = 0.71, AUC = 0.71) and Logistic Regression (sensitivity = 0.71, specificity = 0.72, accuracy = 0.71, AUC = 0.71). The models showed and accuracy of about 70% when tested on the validation population. Conclusions: Wall ultrastructure of radial arteries of FMD patients is extensively altered: IMT and AT are thickened and the first and/or second layer of the arterial wall is splitted, showing a triple signal feature. Radiomic descriptors combined with engineered parameters allow to distinguish between radial images from FMD patients and controls with a 70% accuracy.https://www.atlantis-press.com/article/125950093/view |
| spellingShingle | Federica Poli Rosa Maria Bruno Francesco Faita Hakim Khettab Michel Azizi Saverio Vitali Mirco Cosottini Davide Caramella Lorenzo Ghiadoni Stefano Taddei Pierre Boutouyrie Alexandre Persu Xavier Jeunemaitre Aurélien Lorthioir P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach Artery Research |
| title | P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach |
| title_full | P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach |
| title_fullStr | P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach |
| title_full_unstemmed | P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach |
| title_short | P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach |
| title_sort | p 50 radial artery phenotyping in fibromuscular dysplasia through ultra high frequency ultrasound a radiomic approach |
| url | https://www.atlantis-press.com/article/125950093/view |
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