CD80 expression promotes immune surveillance in Barrett’s metaplasia
Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell efficacy. Here we report for the first time the rol...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-10-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/2162402X.2019.1636618 |
| _version_ | 1828786402059354112 |
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| author | Melania Scarpa Matteo Fassan Andromachi Kotsafti Stefano Realdon Luigi Dall’Olmo Tiziana Morbin Francesco Cavallin Luca Saadeh Matteo Cagol Rita Alfieri Carlo Castoro Massimo Rugge Ignazio Castagliuolo Marco Scarpa |
| author_facet | Melania Scarpa Matteo Fassan Andromachi Kotsafti Stefano Realdon Luigi Dall’Olmo Tiziana Morbin Francesco Cavallin Luca Saadeh Matteo Cagol Rita Alfieri Carlo Castoro Massimo Rugge Ignazio Castagliuolo Marco Scarpa |
| author_sort | Melania Scarpa |
| collection | DOAJ |
| description | Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell efficacy. Here we report for the first time the role of CD80 in the inflammatory esophageal carcinogenesis and characterize the immune environment of EAC. Mucosa samples from cancer were obtained during esophagectomy from patients affected by EAC. Fresh biopsies were obtained from patients who underwent endoscopy for screening or follow-up. A rodent model of reflux induced esophageal carcinogenesis was created with an esophago-gastro-jejunostomy. CD80 expression was increased in epithelial cells during metaplasia in the inflammatory esophageal carcinogenesis cascade. Cd80 null mice as well as WT mice that received antiCD80 antibodies showed a higher rate of dysplasia and KI-67+ cells. These results suggest that CD80 mediates an active immune surveillance process in early inflammation-driven esophageal carcinogenesis. |
| first_indexed | 2024-12-12T00:09:29Z |
| format | Article |
| id | doaj.art-8df0e08859b741698002c7f43ea5d1e6 |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-12-12T00:09:29Z |
| publishDate | 2019-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-8df0e08859b741698002c7f43ea5d1e62022-12-22T00:45:00ZengTaylor & Francis GroupOncoImmunology2162-402X2019-10-0181010.1080/2162402X.2019.16366181636618CD80 expression promotes immune surveillance in Barrett’s metaplasiaMelania Scarpa0Matteo Fassan1Andromachi Kotsafti2Stefano Realdon3Luigi Dall’Olmo4Tiziana Morbin5Francesco Cavallin6Luca Saadeh7Matteo Cagol8Rita Alfieri9Carlo Castoro10Massimo Rugge11Ignazio Castagliuolo12Marco Scarpa13IRCCSUniversity of PaduaIRCCSHospital of VeniceHospital of VeniceHospital of VeniceIndependent StatisticianUniversity Hospital of PadovaHospital of VeniceHospital of VeniceHumanitas Research Hospital-Humanitas UniversityUniversity of PaduaUniversity of PaduaUniversity Hospital of PadovaEsophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell efficacy. Here we report for the first time the role of CD80 in the inflammatory esophageal carcinogenesis and characterize the immune environment of EAC. Mucosa samples from cancer were obtained during esophagectomy from patients affected by EAC. Fresh biopsies were obtained from patients who underwent endoscopy for screening or follow-up. A rodent model of reflux induced esophageal carcinogenesis was created with an esophago-gastro-jejunostomy. CD80 expression was increased in epithelial cells during metaplasia in the inflammatory esophageal carcinogenesis cascade. Cd80 null mice as well as WT mice that received antiCD80 antibodies showed a higher rate of dysplasia and KI-67+ cells. These results suggest that CD80 mediates an active immune surveillance process in early inflammation-driven esophageal carcinogenesis.http://dx.doi.org/10.1080/2162402X.2019.1636618barrett’s esophagusesophageal dysplasiaimmune surveillancecd80adenocarcinoma |
| spellingShingle | Melania Scarpa Matteo Fassan Andromachi Kotsafti Stefano Realdon Luigi Dall’Olmo Tiziana Morbin Francesco Cavallin Luca Saadeh Matteo Cagol Rita Alfieri Carlo Castoro Massimo Rugge Ignazio Castagliuolo Marco Scarpa CD80 expression promotes immune surveillance in Barrett’s metaplasia OncoImmunology barrett’s esophagus esophageal dysplasia immune surveillance cd80 adenocarcinoma |
| title | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
| title_full | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
| title_fullStr | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
| title_full_unstemmed | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
| title_short | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
| title_sort | cd80 expression promotes immune surveillance in barrett s metaplasia |
| topic | barrett’s esophagus esophageal dysplasia immune surveillance cd80 adenocarcinoma |
| url | http://dx.doi.org/10.1080/2162402X.2019.1636618 |
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