Optimization of Ultrasound-mediated Anti-angiogenic Cancer Gene Therapy

Optimization of Ultrasound-mediated Anti-angiogenic Cancer Gene Therapy

Ultrasound-targeted microbubble destruction (UTMD) can be used to deliver silencing gene therapy to tumors. We hypothesized that UTMD would be effective in suppressing angiogenesis within tumors, and that modulation of the ultrasound pulsing intervals (PI) during UTMD would affect the magnitude of t...

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Bibliographic Details
Main Authors: Hiroko Fujii, Pratiek Matkar, Christine Liao, Dmitriy Rudenko, Paul JH Lee, Michael A Kuliszewski, Gerald J Prud'homme, Howard Leong-Poi
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
angiogenesis
cancer
gene therapy
microbubbles
ultrasound
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301524

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