Durable Responses to Anti-PD1 and Anti-CTLA4 in a Preclinical Model of Melanoma Displaying Key Immunotherapy Response Biomarkers

Durable Responses to Anti-PD1 and Anti-CTLA4 in a Preclinical Model of Melanoma Displaying Key Immunotherapy Response Biomarkers

Immunotherapy has transformed the management of patients with advanced melanoma, with five-year overall survival rates reaching 52% for combination immunotherapies blocking the cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) and programmed cell death-1 (PD1) immune axes. Yet, our understanding o...

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Bibliographic Details
Main Authors:	Elena Shklovskaya, Bernadette Pedersen, Ashleigh Stewart, Jack O. G. Simpson, Zizhen Ming, Mal Irvine, Richard A. Scolyer, Georgina V. Long, Helen Rizos
Format:	Article
Language:	English
Published:	MDPI AG 2022-10-01
Series:	Cancers
Subjects:	immune checkpoint blockade melanoma mouse models antigen presentation major histocompatibility (MHC) class I interferon
Online Access:	https://www.mdpi.com/2072-6694/14/19/4830

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