Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against renal ischemia/reperfusion injury by inhibiting inflammation

Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against renal ischemia/reperfusion injury by inhibiting inflammation

Hypoxia-induced inflammation is the critical pathological feature of acute kidney injury (AKI). Activation of hypoxia-inducible factor (HIF) signaling is considered as a central mechanism of body adapting to hypoxia. Hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 (Roxadustat) is a fir...

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Bibliographic Details
Main Authors: A-Feng Miao, Jian-Xiang Liang, Lei Yao, Jun-Ling Han, Li-Juan Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Renal Failure
Subjects:
fg-4592
renal ischemia/reperfusion injury
inflammation
Online Access:http://dx.doi.org/10.1080/0886022X.2021.1915801

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