Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy
Despite the options available for breast cancer (BC) therapy, several adverse effects and resistance limit the success of the treatment. Furthermore, the use of a single drug is associated with a high failure rate. We investigated through a systematic review the in vitro effects of the combination b...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/275 |
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| author | Lyvia Eloiza de Freitas Meirelles Maria Vitória Felipe de Souza Lucimara Rodrigues Carobeli Fabrício Morelli Natália Lourenço Mari Edilson Damke Cristiane Suemi Shinobu Mesquita Jorge Juarez Vieira Teixeira Marcia Edilaine Lopes Consolaro Vânia Ramos Sela da Silva |
| author_facet | Lyvia Eloiza de Freitas Meirelles Maria Vitória Felipe de Souza Lucimara Rodrigues Carobeli Fabrício Morelli Natália Lourenço Mari Edilson Damke Cristiane Suemi Shinobu Mesquita Jorge Juarez Vieira Teixeira Marcia Edilaine Lopes Consolaro Vânia Ramos Sela da Silva |
| author_sort | Lyvia Eloiza de Freitas Meirelles |
| collection | DOAJ |
| description | Despite the options available for breast cancer (BC) therapy, several adverse effects and resistance limit the success of the treatment. Furthermore, the use of a single drug is associated with a high failure rate. We investigated through a systematic review the in vitro effects of the combination between conventional drugs and bioactive compounds derived from cinnamic acid in BC treatment. The information was acquired from the following databases: PubMed, Web of Science, Embase, Scopus, Lilacs and Cochrane library. We focused on “Cinnamates”, “Drug Combinations” and “Breast neoplasms” for publications dating between January 2012 and December 2022, based on the PRISMA statement. The references of the articles were carefully reviewed. Finally, nine eligible studies were included. The majority of these studies were performed using MCF-7, MDA-MB-231, MDA-MB-468 and BT-20 cell lines and the combination between cisplatin, paclitaxel, doxorubicin, tamoxifen, dactolisib and veliparib, with caffeic acid phenethyl ester, eugenol, 3-caffeoylquinic acid, salvianolic acid A, ferulic acid, caffeic acid, rosmarinic acid and ursolic acid. The combination improved overall conventional drug effects, with increased cytotoxicity, antimigratory effect and reversing resistance. Combining conventional drugs with bioactive compounds derived from cinnamic acid could emerge as a privileged scaffold for establishing new treatment options for different BC types. |
| first_indexed | 2024-03-11T09:07:34Z |
| format | Article |
| id | doaj.art-8df7c51b7bd94704af885eed1b846b70 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:07:34Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-8df7c51b7bd94704af885eed1b846b702023-11-16T19:15:47ZengMDPI AGBiomedicines2227-90592023-01-0111227510.3390/biomedicines11020275Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer TherapyLyvia Eloiza de Freitas Meirelles0Maria Vitória Felipe de Souza1Lucimara Rodrigues Carobeli2Fabrício Morelli3Natália Lourenço Mari4Edilson Damke5Cristiane Suemi Shinobu Mesquita6Jorge Juarez Vieira Teixeira7Marcia Edilaine Lopes Consolaro8Vânia Ramos Sela da Silva9Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, BrazilDespite the options available for breast cancer (BC) therapy, several adverse effects and resistance limit the success of the treatment. Furthermore, the use of a single drug is associated with a high failure rate. We investigated through a systematic review the in vitro effects of the combination between conventional drugs and bioactive compounds derived from cinnamic acid in BC treatment. The information was acquired from the following databases: PubMed, Web of Science, Embase, Scopus, Lilacs and Cochrane library. We focused on “Cinnamates”, “Drug Combinations” and “Breast neoplasms” for publications dating between January 2012 and December 2022, based on the PRISMA statement. The references of the articles were carefully reviewed. Finally, nine eligible studies were included. The majority of these studies were performed using MCF-7, MDA-MB-231, MDA-MB-468 and BT-20 cell lines and the combination between cisplatin, paclitaxel, doxorubicin, tamoxifen, dactolisib and veliparib, with caffeic acid phenethyl ester, eugenol, 3-caffeoylquinic acid, salvianolic acid A, ferulic acid, caffeic acid, rosmarinic acid and ursolic acid. The combination improved overall conventional drug effects, with increased cytotoxicity, antimigratory effect and reversing resistance. Combining conventional drugs with bioactive compounds derived from cinnamic acid could emerge as a privileged scaffold for establishing new treatment options for different BC types.https://www.mdpi.com/2227-9059/11/2/275breast neoplasmstherapeuticsdrug combinationscinnamatesdrug synergism |
| spellingShingle | Lyvia Eloiza de Freitas Meirelles Maria Vitória Felipe de Souza Lucimara Rodrigues Carobeli Fabrício Morelli Natália Lourenço Mari Edilson Damke Cristiane Suemi Shinobu Mesquita Jorge Juarez Vieira Teixeira Marcia Edilaine Lopes Consolaro Vânia Ramos Sela da Silva Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy Biomedicines breast neoplasms therapeutics drug combinations cinnamates drug synergism |
| title | Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy |
| title_full | Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy |
| title_fullStr | Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy |
| title_full_unstemmed | Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy |
| title_short | Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy |
| title_sort | combination of conventional drugs with biocompounds derived from cinnamic acid a promising option for breast cancer therapy |
| topic | breast neoplasms therapeutics drug combinations cinnamates drug synergism |
| url | https://www.mdpi.com/2227-9059/11/2/275 |
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