Associations between the gut microbiome and fatigue in cancer patients
Abstract Fatigue is the most prevalent symptom of cancer and its treatments. Changes in the intestinal microbiome have been identified in chronic fatigue syndrome and other neuropsychiatric disorders, and cancer patients. However, the association between intestinal microbiome and fatigue in patients...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-84783-9 |
| _version_ | 1830194012446785536 |
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| author | Joud Hajjar Tito Mendoza Liangliang Zhang Siqing Fu Sarina A. Piha-Paul David S. Hong Filip Janku Daniel D. Karp Alexej Ballhausen Jing Gong Abdulrazzak Zarifa Christine B. Peterson Funda Meric-Bernstam Robert Jenq Aung Naing |
| author_facet | Joud Hajjar Tito Mendoza Liangliang Zhang Siqing Fu Sarina A. Piha-Paul David S. Hong Filip Janku Daniel D. Karp Alexej Ballhausen Jing Gong Abdulrazzak Zarifa Christine B. Peterson Funda Meric-Bernstam Robert Jenq Aung Naing |
| author_sort | Joud Hajjar |
| collection | DOAJ |
| description | Abstract Fatigue is the most prevalent symptom of cancer and its treatments. Changes in the intestinal microbiome have been identified in chronic fatigue syndrome and other neuropsychiatric disorders, and cancer patients. However, the association between intestinal microbiome and fatigue in patients with advanced cancers has not been evaluated. Understanding the connection between intestinal microbiome and fatigue will provide interventional and therapeutic opportunities to manipulate the microbiome to improve fatigue and other patients’ reported outcomes. In this project, we aimed to identify associations between microbiome composition and fatigue in advanced cancer patients. In this cross-sectional observational study at a tertiary cancer care center, we included 88 patients with advanced, metastatic, unresectable cancers who were in a washout period from chemotherapy. We measured fatigue using the MD Anderson Symptom Inventory—Immunotherapy fatigue score, and used 16srRNA to analyze intestinal microbiome. Using correlation analysis we found that Eubacterium hallii was negatively associated with fatigue severity scores (r = − 0.30, p = 0.005), whereas Cosenzaea was positively associated with fatigue scores (r = 0.33, p = 0.0002). We identified microbial species that exhibit distinct composition between high-fatigued and low-fatigued cancer patients. Further studies are warranted to investigate whether modulating the microbiome reduces cancer patients’ fatigue severity and improves their quality of life. |
| first_indexed | 2024-12-18T00:22:03Z |
| format | Article |
| id | doaj.art-8df7e07740964adfadc98678f9ef6a50 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T00:22:03Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8df7e07740964adfadc98678f9ef6a502022-12-21T21:27:19ZengNature PortfolioScientific Reports2045-23222021-03-0111111010.1038/s41598-021-84783-9Associations between the gut microbiome and fatigue in cancer patientsJoud Hajjar0Tito Mendoza1Liangliang Zhang2Siqing Fu3Sarina A. Piha-Paul4David S. Hong5Filip Janku6Daniel D. Karp7Alexej Ballhausen8Jing Gong9Abdulrazzak Zarifa10Christine B. Peterson11Funda Meric-Bernstam12Robert Jenq13Aung Naing14Department of Pediatrics, Baylor College of MedicineDepartment of Symptom Research, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer CenterAbstract Fatigue is the most prevalent symptom of cancer and its treatments. Changes in the intestinal microbiome have been identified in chronic fatigue syndrome and other neuropsychiatric disorders, and cancer patients. However, the association between intestinal microbiome and fatigue in patients with advanced cancers has not been evaluated. Understanding the connection between intestinal microbiome and fatigue will provide interventional and therapeutic opportunities to manipulate the microbiome to improve fatigue and other patients’ reported outcomes. In this project, we aimed to identify associations between microbiome composition and fatigue in advanced cancer patients. In this cross-sectional observational study at a tertiary cancer care center, we included 88 patients with advanced, metastatic, unresectable cancers who were in a washout period from chemotherapy. We measured fatigue using the MD Anderson Symptom Inventory—Immunotherapy fatigue score, and used 16srRNA to analyze intestinal microbiome. Using correlation analysis we found that Eubacterium hallii was negatively associated with fatigue severity scores (r = − 0.30, p = 0.005), whereas Cosenzaea was positively associated with fatigue scores (r = 0.33, p = 0.0002). We identified microbial species that exhibit distinct composition between high-fatigued and low-fatigued cancer patients. Further studies are warranted to investigate whether modulating the microbiome reduces cancer patients’ fatigue severity and improves their quality of life.https://doi.org/10.1038/s41598-021-84783-9 |
| spellingShingle | Joud Hajjar Tito Mendoza Liangliang Zhang Siqing Fu Sarina A. Piha-Paul David S. Hong Filip Janku Daniel D. Karp Alexej Ballhausen Jing Gong Abdulrazzak Zarifa Christine B. Peterson Funda Meric-Bernstam Robert Jenq Aung Naing Associations between the gut microbiome and fatigue in cancer patients Scientific Reports |
| title | Associations between the gut microbiome and fatigue in cancer patients |
| title_full | Associations between the gut microbiome and fatigue in cancer patients |
| title_fullStr | Associations between the gut microbiome and fatigue in cancer patients |
| title_full_unstemmed | Associations between the gut microbiome and fatigue in cancer patients |
| title_short | Associations between the gut microbiome and fatigue in cancer patients |
| title_sort | associations between the gut microbiome and fatigue in cancer patients |
| url | https://doi.org/10.1038/s41598-021-84783-9 |
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