Clinical Features of Late-Onset Circulatory Collapse in Preterm Infants
Purpose This study aimed to investigate the incidence and clinical features of late-onset circulatory collapse (LCC) in preterm infants. Methods Medical records of 327 preterm infants (born before 32 gestational weeks) admitted to the neonatal intensive care unit of Seoul National University Bundang...
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| Format: | Article |
| Language: | English |
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Korean Society of Neonatology
2019-08-01
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| Series: | Neonatal Medicine |
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| Online Access: | http://www.neo-med.org/upload/pdf/nm-2019-26-3-128.pdf |
| _version_ | 1819277364953088000 |
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| author | Jin Hee Jang Jeongmin Shin Young Hwa Jung Chang Won Choi Beyong Il Kim |
| author_facet | Jin Hee Jang Jeongmin Shin Young Hwa Jung Chang Won Choi Beyong Il Kim |
| author_sort | Jin Hee Jang |
| collection | DOAJ |
| description | Purpose This study aimed to investigate the incidence and clinical features of late-onset circulatory collapse (LCC) in preterm infants. Methods Medical records of 327 preterm infants (born before 32 gestational weeks) admitted to the neonatal intensive care unit of Seoul National University Bundang Hospital between January 2014 and December 2017 were reviewed. LCC was defined as sudden onset of refractory hypotension occurring after 7 days of life without obvious causes, which responded to glucocorticoid administration. Clinical characteristics and outcomes in infants with LCC were compared with those in infants with hypotension associated with identifiable causes, which developed after 7 days of life. Results Among 327 preterm infants who enrolled in this study, 65 infants developed hypotension with oliguria after 7 days of life. Among these 65 infants, 35 (53.8%) met the criteria for LCC and 30 (46.2%) were diagnosed with hypotension associated with other identifiable causes. No statistically significant differences were observed in the baseline pre- and perinatal characteristics between infants with LCC and those with hypotension associated with other causes. Infants with hypotension associated with other causes showed a higher mortality rate than those with LCC (33.3% vs. 5.7%, P=0.004). The mean gestational age and birth weight of 27+5±2+1 weeks and 963±245 g, respectively. LCC occurred at a mean postnatal age of 18 days. The median body weight at the time of diagnosis of LCC was 1,200 g. No association was observed between LCC and gestational age. Conclusion Among preterm infants born before 32 gestational weeks who developed hypotension after 7 days of life, nearly 50% were diagnosed with LCC without apparent identifiable causes. Infants with LCC showed a lower mortality rate than those with hypotension associated with other causes. |
| first_indexed | 2024-12-23T23:54:57Z |
| format | Article |
| id | doaj.art-8df97a747b92470abecf5541aafa1280 |
| institution | Directory Open Access Journal |
| issn | 2287-9412 2287-9803 |
| language | English |
| last_indexed | 2024-12-23T23:54:57Z |
| publishDate | 2019-08-01 |
| publisher | Korean Society of Neonatology |
| record_format | Article |
| series | Neonatal Medicine |
| spelling | doaj.art-8df97a747b92470abecf5541aafa12802022-12-21T17:25:17ZengKorean Society of NeonatologyNeonatal Medicine2287-94122287-98032019-08-0126312813710.5385/nm.2019.26.3.128971Clinical Features of Late-Onset Circulatory Collapse in Preterm InfantsJin Hee Jang0Jeongmin Shin1Young Hwa Jung2Chang Won Choi3Beyong Il Kim4 Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, KoreaPurpose This study aimed to investigate the incidence and clinical features of late-onset circulatory collapse (LCC) in preterm infants. Methods Medical records of 327 preterm infants (born before 32 gestational weeks) admitted to the neonatal intensive care unit of Seoul National University Bundang Hospital between January 2014 and December 2017 were reviewed. LCC was defined as sudden onset of refractory hypotension occurring after 7 days of life without obvious causes, which responded to glucocorticoid administration. Clinical characteristics and outcomes in infants with LCC were compared with those in infants with hypotension associated with identifiable causes, which developed after 7 days of life. Results Among 327 preterm infants who enrolled in this study, 65 infants developed hypotension with oliguria after 7 days of life. Among these 65 infants, 35 (53.8%) met the criteria for LCC and 30 (46.2%) were diagnosed with hypotension associated with other identifiable causes. No statistically significant differences were observed in the baseline pre- and perinatal characteristics between infants with LCC and those with hypotension associated with other causes. Infants with hypotension associated with other causes showed a higher mortality rate than those with LCC (33.3% vs. 5.7%, P=0.004). The mean gestational age and birth weight of 27+5±2+1 weeks and 963±245 g, respectively. LCC occurred at a mean postnatal age of 18 days. The median body weight at the time of diagnosis of LCC was 1,200 g. No association was observed between LCC and gestational age. Conclusion Among preterm infants born before 32 gestational weeks who developed hypotension after 7 days of life, nearly 50% were diagnosed with LCC without apparent identifiable causes. Infants with LCC showed a lower mortality rate than those with hypotension associated with other causes.http://www.neo-med.org/upload/pdf/nm-2019-26-3-128.pdflate-onset circulatory collapsehypotensionhydrocortisoneinfant, premature |
| spellingShingle | Jin Hee Jang Jeongmin Shin Young Hwa Jung Chang Won Choi Beyong Il Kim Clinical Features of Late-Onset Circulatory Collapse in Preterm Infants Neonatal Medicine late-onset circulatory collapse hypotension hydrocortisone infant, premature |
| title | Clinical Features of Late-Onset Circulatory Collapse in Preterm Infants |
| title_full | Clinical Features of Late-Onset Circulatory Collapse in Preterm Infants |
| title_fullStr | Clinical Features of Late-Onset Circulatory Collapse in Preterm Infants |
| title_full_unstemmed | Clinical Features of Late-Onset Circulatory Collapse in Preterm Infants |
| title_short | Clinical Features of Late-Onset Circulatory Collapse in Preterm Infants |
| title_sort | clinical features of late onset circulatory collapse in preterm infants |
| topic | late-onset circulatory collapse hypotension hydrocortisone infant, premature |
| url | http://www.neo-med.org/upload/pdf/nm-2019-26-3-128.pdf |
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