Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease
BackgroundThe coronary calcium score (CAC) measured on chest computerized tomography is a risk marker of cardiac events and mortality. We compared CAC scores in two multiethnic groups without symptomatic coronary artery disease: subjects in the chronic phase after stroke or transient ischemic attack...
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1082275/full |
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| author | Ana Luíza Vieira de Araújo Raul D. Santos Raul D. Santos Marcio Sommer Bittencourt Roberto Nery Dantas Roberto Nery Dantas Carlos André Oshiro Cesar Higa Nomura Cesar Higa Nomura Edson Bor-Seng-Shu Marcelo de Lima Oliveira Claudia da Costa Leite Maria da Graça Morais Martin Maramelia Miranda Alves Gisele Sampaio Silva Victor Marinho Silva Adriana Bastos Conforto |
| author_facet | Ana Luíza Vieira de Araújo Raul D. Santos Raul D. Santos Marcio Sommer Bittencourt Roberto Nery Dantas Roberto Nery Dantas Carlos André Oshiro Cesar Higa Nomura Cesar Higa Nomura Edson Bor-Seng-Shu Marcelo de Lima Oliveira Claudia da Costa Leite Maria da Graça Morais Martin Maramelia Miranda Alves Gisele Sampaio Silva Victor Marinho Silva Adriana Bastos Conforto |
| author_sort | Ana Luíza Vieira de Araújo |
| collection | DOAJ |
| description | BackgroundThe coronary calcium score (CAC) measured on chest computerized tomography is a risk marker of cardiac events and mortality. We compared CAC scores in two multiethnic groups without symptomatic coronary artery disease: subjects in the chronic phase after stroke or transient ischemic attack and at least one symptomatic stenosis ≥50% in the carotid or vertebrobasilar territories (Groupathero) and a control group (Groupcontrol).MethodsIn this cross-sectional study, Groupathero included two subgroups: GroupExtraorIntra, with stenoses in either cervical or intracranial arteries, and GroupExtra&Intra, with stenoses in at least one cervical and one intracranial artery. Groupcontrol had no history of prior stroke/transient ischemic attacks and no stenoses ≥50% in cervical or intracranial arteries. Age and sex were comparable in all groups. Frequencies of CAC ≥100 and CAC > 0 were compared between Groupathero and Groupcontrol, as well as between GroupExtraorIntr, GroupExtra&Intra, and Groupcontrol, with bivariate logistic regressions. Multivariate analyses were also performed.ResultsA total of 120 patients were included: 80 in Groupathero and 40 in Groupcontrol. CAC >0 was significantly more frequent in Groupathero (85%) than Groupcontrol (OR, 4.19; 1.74–10.07; p = 0.001). Rates of CAC ≥100 were not significantly different between Groupathero and Groupcontrol but were significantly greater in GroupExtra&Intra (n = 13) when compared to Groupcontrol (OR 4.67; 1.21–18.04; p = 0.025). In multivariate-adjusted analyses, “Groupathero” and “GroupExtra&Intra” were significantly associated with CAC.ConclusionThe frequency of coronary calcification was higher in subjects with stroke caused by large-artery atherosclerosis than in controls. |
| first_indexed | 2024-04-09T18:24:29Z |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T18:24:29Z |
| publishDate | 2023-04-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-8dfd5030b16a4eb3b29f2a6167f71ff32023-04-12T04:53:59ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.10822751082275Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery diseaseAna Luíza Vieira de Araújo0Raul D. Santos1Raul D. Santos2Marcio Sommer Bittencourt3Roberto Nery Dantas4Roberto Nery Dantas5Carlos André Oshiro6Cesar Higa Nomura7Cesar Higa Nomura8Edson Bor-Seng-Shu9Marcelo de Lima Oliveira10Claudia da Costa Leite11Maria da Graça Morais Martin12Maramelia Miranda Alves13Gisele Sampaio Silva14Victor Marinho Silva15Adriana Bastos Conforto16Hospital das Clinicas, Neurology Clinical Division, University of São Paulo, São Paulo, BrazilHeart Institute (Instituto do Coração), University of São Paulo, Medical School Hospital, São Paulo, BrazilHospital Israelita Albert Einstein, Academic Research Organization, São Paulo, BrazilDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesHeart Institute (Instituto do Coração), University of São Paulo, Medical School Hospital, São Paulo, BrazilHospital Israelita Albert Einstein, Academic Research Organization, São Paulo, BrazilHospital das Clinicas, Neurology Clinical Division, University of São Paulo, São Paulo, BrazilHeart Institute (Instituto do Coração), University of São Paulo, Medical School Hospital, São Paulo, BrazilHospital Israelita Albert Einstein, Academic Research Organization, São Paulo, BrazilHospital das Clinicas, Neurology Clinical Division, University of São Paulo, São Paulo, BrazilHospital das Clinicas, Neurology Clinical Division, University of São Paulo, São Paulo, BrazilDepartment of Radiology and Oncology, University of São Paulo, São Paulo, BrazilDepartment of Radiology and Oncology, University of São Paulo, São Paulo, BrazilNeurology and Neurosurgery Department, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilNeurology and Neurosurgery Department, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilHospital das Clinicas, Neurology Clinical Division, University of São Paulo, São Paulo, BrazilHospital das Clinicas, Neurology Clinical Division, University of São Paulo, São Paulo, BrazilBackgroundThe coronary calcium score (CAC) measured on chest computerized tomography is a risk marker of cardiac events and mortality. We compared CAC scores in two multiethnic groups without symptomatic coronary artery disease: subjects in the chronic phase after stroke or transient ischemic attack and at least one symptomatic stenosis ≥50% in the carotid or vertebrobasilar territories (Groupathero) and a control group (Groupcontrol).MethodsIn this cross-sectional study, Groupathero included two subgroups: GroupExtraorIntra, with stenoses in either cervical or intracranial arteries, and GroupExtra&Intra, with stenoses in at least one cervical and one intracranial artery. Groupcontrol had no history of prior stroke/transient ischemic attacks and no stenoses ≥50% in cervical or intracranial arteries. Age and sex were comparable in all groups. Frequencies of CAC ≥100 and CAC > 0 were compared between Groupathero and Groupcontrol, as well as between GroupExtraorIntr, GroupExtra&Intra, and Groupcontrol, with bivariate logistic regressions. Multivariate analyses were also performed.ResultsA total of 120 patients were included: 80 in Groupathero and 40 in Groupcontrol. CAC >0 was significantly more frequent in Groupathero (85%) than Groupcontrol (OR, 4.19; 1.74–10.07; p = 0.001). Rates of CAC ≥100 were not significantly different between Groupathero and Groupcontrol but were significantly greater in GroupExtra&Intra (n = 13) when compared to Groupcontrol (OR 4.67; 1.21–18.04; p = 0.025). In multivariate-adjusted analyses, “Groupathero” and “GroupExtra&Intra” were significantly associated with CAC.ConclusionThe frequency of coronary calcification was higher in subjects with stroke caused by large-artery atherosclerosis than in controls.https://www.frontiersin.org/articles/10.3389/fneur.2023.1082275/fullischemic strokecoronary calcium scoresubclinical coronary artery diseasecoronary atherosclerosiscervicocephalic atherosclerosis |
| spellingShingle | Ana Luíza Vieira de Araújo Raul D. Santos Raul D. Santos Marcio Sommer Bittencourt Roberto Nery Dantas Roberto Nery Dantas Carlos André Oshiro Cesar Higa Nomura Cesar Higa Nomura Edson Bor-Seng-Shu Marcelo de Lima Oliveira Claudia da Costa Leite Maria da Graça Morais Martin Maramelia Miranda Alves Gisele Sampaio Silva Victor Marinho Silva Adriana Bastos Conforto Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease Frontiers in Neurology ischemic stroke coronary calcium score subclinical coronary artery disease coronary atherosclerosis cervicocephalic atherosclerosis |
| title | Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease |
| title_full | Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease |
| title_fullStr | Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease |
| title_full_unstemmed | Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease |
| title_short | Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease |
| title_sort | ischemic stroke caused by large artery atherosclerosis a red flag for subclinical coronary artery disease |
| topic | ischemic stroke coronary calcium score subclinical coronary artery disease coronary atherosclerosis cervicocephalic atherosclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1082275/full |
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