Safety Properties of <i>Escherichia coli</i> O157:H7 Specific Bacteriophages: Recent Advances for Food Safety
Shiga-toxin-producing <i>Escherichia coli</i> (STEC) is typically detected on food products mainly due to cross-contamination with faecal matter. The serotype O157:H7 has been of major public health concern due to the severity of illness caused, prevalence, and management. In the food ch...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/21/3989 |
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| author | Bukola Opeyemi Oluwarinde Daniel Jesuwenu Ajose Tesleem Olatunde Abolarinwa Peter Kotsoana Montso Ilse Du Preez Henry Akum Njom Collins Njie Ateba |
| author_facet | Bukola Opeyemi Oluwarinde Daniel Jesuwenu Ajose Tesleem Olatunde Abolarinwa Peter Kotsoana Montso Ilse Du Preez Henry Akum Njom Collins Njie Ateba |
| author_sort | Bukola Opeyemi Oluwarinde |
| collection | DOAJ |
| description | Shiga-toxin-producing <i>Escherichia coli</i> (STEC) is typically detected on food products mainly due to cross-contamination with faecal matter. The serotype O157:H7 has been of major public health concern due to the severity of illness caused, prevalence, and management. In the food chain, the main methods of controlling contamination by foodborne pathogens often involve the application of antimicrobial agents, which are now becoming less efficient. There is a growing need for the development of new approaches to combat these pathogens, especially those that harbour antimicrobial resistant and virulent determinants. Strategies to also limit their presence on food contact surfaces and food matrices are needed to prevent their transmission. Recent studies have revealed that bacteriophages are useful non-antibiotic options for biocontrol of <i>E. coli</i> O157:H7 in both animals and humans. Phage biocontrol can significantly reduce <i>E. coli</i> O157:H7, thereby improving food safety. However, before being certified as potential biocontrol agents, the safety of the phage candidates must be resolved to satisfy regulatory standards, particularly regarding phage resistance, antigenic properties, and toxigenic properties. In this review, we provide a general description of the main virulence elements of <i>E. coli</i> O157:H7 and present detailed reports that support the proposals that phages infecting <i>E. coli</i> O157:H7 are potential biocontrol agents. This paper also outlines the mechanism of <i>E. coli</i> O157:H7 resistance to phages and the safety concerns associated with the use of phages as a biocontrol. |
| first_indexed | 2024-03-11T11:29:52Z |
| format | Article |
| id | doaj.art-8dfe577d5f954cefbc5046f015ceddce |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-11T11:29:52Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-8dfe577d5f954cefbc5046f015ceddce2023-11-10T15:02:58ZengMDPI AGFoods2304-81582023-10-011221398910.3390/foods12213989Safety Properties of <i>Escherichia coli</i> O157:H7 Specific Bacteriophages: Recent Advances for Food SafetyBukola Opeyemi Oluwarinde0Daniel Jesuwenu Ajose1Tesleem Olatunde Abolarinwa2Peter Kotsoana Montso3Ilse Du Preez4Henry Akum Njom5Collins Njie Ateba6Food Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mahikeng 2375, South AfricaFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mahikeng 2375, South AfricaFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mahikeng 2375, South AfricaFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mahikeng 2375, South AfricaCentre for Human Metabolomics, North-West University, Potchefstroom 2531, South AfricaAgricultural Research Council, Private Bag X1251, Potchefstroom 2531, South AfricaFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mahikeng 2375, South AfricaShiga-toxin-producing <i>Escherichia coli</i> (STEC) is typically detected on food products mainly due to cross-contamination with faecal matter. The serotype O157:H7 has been of major public health concern due to the severity of illness caused, prevalence, and management. In the food chain, the main methods of controlling contamination by foodborne pathogens often involve the application of antimicrobial agents, which are now becoming less efficient. There is a growing need for the development of new approaches to combat these pathogens, especially those that harbour antimicrobial resistant and virulent determinants. Strategies to also limit their presence on food contact surfaces and food matrices are needed to prevent their transmission. Recent studies have revealed that bacteriophages are useful non-antibiotic options for biocontrol of <i>E. coli</i> O157:H7 in both animals and humans. Phage biocontrol can significantly reduce <i>E. coli</i> O157:H7, thereby improving food safety. However, before being certified as potential biocontrol agents, the safety of the phage candidates must be resolved to satisfy regulatory standards, particularly regarding phage resistance, antigenic properties, and toxigenic properties. In this review, we provide a general description of the main virulence elements of <i>E. coli</i> O157:H7 and present detailed reports that support the proposals that phages infecting <i>E. coli</i> O157:H7 are potential biocontrol agents. This paper also outlines the mechanism of <i>E. coli</i> O157:H7 resistance to phages and the safety concerns associated with the use of phages as a biocontrol.https://www.mdpi.com/2304-8158/12/21/3989food borne infectionantimicrobial resistance<i>Escherichia coli</i> O157:H7phage therapywhole genome sequencingone health approach |
| spellingShingle | Bukola Opeyemi Oluwarinde Daniel Jesuwenu Ajose Tesleem Olatunde Abolarinwa Peter Kotsoana Montso Ilse Du Preez Henry Akum Njom Collins Njie Ateba Safety Properties of <i>Escherichia coli</i> O157:H7 Specific Bacteriophages: Recent Advances for Food Safety Foods food borne infection antimicrobial resistance <i>Escherichia coli</i> O157:H7 phage therapy whole genome sequencing one health approach |
| title | Safety Properties of <i>Escherichia coli</i> O157:H7 Specific Bacteriophages: Recent Advances for Food Safety |
| title_full | Safety Properties of <i>Escherichia coli</i> O157:H7 Specific Bacteriophages: Recent Advances for Food Safety |
| title_fullStr | Safety Properties of <i>Escherichia coli</i> O157:H7 Specific Bacteriophages: Recent Advances for Food Safety |
| title_full_unstemmed | Safety Properties of <i>Escherichia coli</i> O157:H7 Specific Bacteriophages: Recent Advances for Food Safety |
| title_short | Safety Properties of <i>Escherichia coli</i> O157:H7 Specific Bacteriophages: Recent Advances for Food Safety |
| title_sort | safety properties of i escherichia coli i o157 h7 specific bacteriophages recent advances for food safety |
| topic | food borne infection antimicrobial resistance <i>Escherichia coli</i> O157:H7 phage therapy whole genome sequencing one health approach |
| url | https://www.mdpi.com/2304-8158/12/21/3989 |
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