Rational Design and Synthesis of Large Stokes Shift 2,6-Sulphur-Disubstituted BODIPYs for Cell Imaging

Rational Design and Synthesis of Large Stokes Shift 2,6-Sulphur-Disubstituted BODIPYs for Cell Imaging

Five new disubstituted 2,6-thioaryl-BODIPY dyes were synthesized via selective aromatic electrophilic substitution from commercially available thiophenols. The analysis of the photophysical properties via absorption and emission spectroscopy showed unusually large Stokes shifts for BODIPY fluorophor...

Full description

Bibliographic Details
Main Authors: Abigail E. Reese, Charles Lochenie, Ailsa Geddis, Luana A. Machado, Marcos C. de Souza, Flávia F. C. Marques, Carlos A. de Simone, Marcos M. Gouvêa, Leandro F. Pedrosa, Eufrânio N. da Silva Júnior, Marc Vendrell
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Chemosensors
Subjects:
fluorophores
probes
microscopy
cytometry
labelling
Online Access:https://www.mdpi.com/2227-9040/10/1/19
Description
Summary:Five new disubstituted 2,6-thioaryl-BODIPY dyes were synthesized via selective aromatic electrophilic substitution from commercially available thiophenols. The analysis of the photophysical properties via absorption and emission spectroscopy showed unusually large Stokes shifts for BODIPY fluorophores (70–100 nm), which makes them suitable probes for bioimaging. Selected compounds were evaluated for labelling primary immune cells as well as different cancer cell lines using confocal fluorescence microscopy.
ISSN:2227-9040

Similar Items