Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples
Background: SRY-related HMG-box 10 (SOX-10) is commonly expressed in triple negative breast cancer (TNBC). However, data on the biological significance of SOX-10 expression is limited. Therefore, we investigated immunhistological SOX-10 expression in TNBC and correlated the results with genetic alte...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/17/6407 |
| _version_ | 1797554717158539264 |
|---|---|
| author | Katharina Kriegsmann Christa Flechtenmacher Jörg Heil Jörg Kriegsmann Gunhild Mechtersheimer Sebastian Aulmann Wilko Weichert Hans-Peter Sinn Mark Kriegsmann |
| author_facet | Katharina Kriegsmann Christa Flechtenmacher Jörg Heil Jörg Kriegsmann Gunhild Mechtersheimer Sebastian Aulmann Wilko Weichert Hans-Peter Sinn Mark Kriegsmann |
| author_sort | Katharina Kriegsmann |
| collection | DOAJ |
| description | Background: SRY-related HMG-box 10 (SOX-10) is commonly expressed in triple negative breast cancer (TNBC). However, data on the biological significance of SOX-10 expression is limited. Therefore, we investigated immunhistological SOX-10 expression in TNBC and correlated the results with genetic alterations and clinical data. Methods: A tissue microarray including 113 TNBC cases was stained by SOX-10. Immunohistological data of AR, BCL2, CD117, p53 and Vimentin was available from a previous study. Semiconductor-based panel sequencing data including commonly altered breast cancer genes was also available from a previous investigation. SOX-10 expression was correlated with clinicopathological, immunohistochemical and genetic data. Results: SOX-10 was significantly associated with CD117 and Vimentin, but not with AR expression. An association of SOX-10 with BCL2, EGFR or p53 staining was not observed. SOX-10-positive tumors harbored more often TP53 mutations but less frequent mutations of PIK3CA or alterations of the PIK3K pathway. SOX-10 expression had no prognostic impact either on disease-free, distant disease-free, or overall survival. Conclusions: While there might be a value of SOX-10 as a differential diagnostic marker to identify metastases of TNBC, its biological role remains to be investigated. |
| first_indexed | 2024-03-10T16:36:01Z |
| format | Article |
| id | doaj.art-8dff6683793f4c94877ee6bab6e09657 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:36:01Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8dff6683793f4c94877ee6bab6e096572023-11-20T12:24:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012117640710.3390/ijms21176407Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 SamplesKatharina Kriegsmann0Christa Flechtenmacher1Jörg Heil2Jörg Kriegsmann3Gunhild Mechtersheimer4Sebastian Aulmann5Wilko Weichert6Hans-Peter Sinn7Mark Kriegsmann8Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, GermanyInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, GermanyBreast Unit, Women’s Hospital, University of Heidelberg, 69120 Heidelberg, GermanyInstitute of Pathology, Cytology and Molecular Pathology, 54296 Trier, GermanyInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, GermanyOptipath Institute of Pathology, 60311 Frankfurt, GermanyInstitute of Pathology, TU Munich, 81675 Munich, GermanyInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, GermanyInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, GermanyBackground: SRY-related HMG-box 10 (SOX-10) is commonly expressed in triple negative breast cancer (TNBC). However, data on the biological significance of SOX-10 expression is limited. Therefore, we investigated immunhistological SOX-10 expression in TNBC and correlated the results with genetic alterations and clinical data. Methods: A tissue microarray including 113 TNBC cases was stained by SOX-10. Immunohistological data of AR, BCL2, CD117, p53 and Vimentin was available from a previous study. Semiconductor-based panel sequencing data including commonly altered breast cancer genes was also available from a previous investigation. SOX-10 expression was correlated with clinicopathological, immunohistochemical and genetic data. Results: SOX-10 was significantly associated with CD117 and Vimentin, but not with AR expression. An association of SOX-10 with BCL2, EGFR or p53 staining was not observed. SOX-10-positive tumors harbored more often TP53 mutations but less frequent mutations of PIK3CA or alterations of the PIK3K pathway. SOX-10 expression had no prognostic impact either on disease-free, distant disease-free, or overall survival. Conclusions: While there might be a value of SOX-10 as a differential diagnostic marker to identify metastases of TNBC, its biological role remains to be investigated.https://www.mdpi.com/1422-0067/21/17/6407SOX10immunohistochemistrytriple-negative breast cancer |
| spellingShingle | Katharina Kriegsmann Christa Flechtenmacher Jörg Heil Jörg Kriegsmann Gunhild Mechtersheimer Sebastian Aulmann Wilko Weichert Hans-Peter Sinn Mark Kriegsmann Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples International Journal of Molecular Sciences SOX10 immunohistochemistry triple-negative breast cancer |
| title | Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples |
| title_full | Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples |
| title_fullStr | Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples |
| title_full_unstemmed | Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples |
| title_short | Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples |
| title_sort | immunohistological expression of sox 10 in triple negative breast cancer a descriptive analysis of 113 samples |
| topic | SOX10 immunohistochemistry triple-negative breast cancer |
| url | https://www.mdpi.com/1422-0067/21/17/6407 |
| work_keys_str_mv | AT katharinakriegsmann immunohistologicalexpressionofsox10intriplenegativebreastcanceradescriptiveanalysisof113samples AT christaflechtenmacher immunohistologicalexpressionofsox10intriplenegativebreastcanceradescriptiveanalysisof113samples AT jorgheil immunohistologicalexpressionofsox10intriplenegativebreastcanceradescriptiveanalysisof113samples AT jorgkriegsmann immunohistologicalexpressionofsox10intriplenegativebreastcanceradescriptiveanalysisof113samples AT gunhildmechtersheimer immunohistologicalexpressionofsox10intriplenegativebreastcanceradescriptiveanalysisof113samples AT sebastianaulmann immunohistologicalexpressionofsox10intriplenegativebreastcanceradescriptiveanalysisof113samples AT wilkoweichert immunohistologicalexpressionofsox10intriplenegativebreastcanceradescriptiveanalysisof113samples AT hanspetersinn immunohistologicalexpressionofsox10intriplenegativebreastcanceradescriptiveanalysisof113samples AT markkriegsmann immunohistologicalexpressionofsox10intriplenegativebreastcanceradescriptiveanalysisof113samples |