Organotypic cocultures as skin equivalents: A complex and sophisticated in vitro system
<p>To assess the role of genes required for skin organogenesis, tissue regeneration and homeostasis, we have established in vitro skin equivalents composed of primary cells or cell lines, respectively. In these organotypic cocultures keratinocytes generate a normal epidermis irrespective of th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2004-01-01
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| Series: | Biological Procedures Online |
| Subjects: | |
| Online Access: | http://www.biologicalprocedures.com/bpo/arts/1/72/m72.htm |
| _version_ | 1818754415709913088 |
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| author | Stark Hans-Jürgen Szabowski Axel Fusenig Norbert E. Maas-Szabowski Nicole |
| author_facet | Stark Hans-Jürgen Szabowski Axel Fusenig Norbert E. Maas-Szabowski Nicole |
| author_sort | Stark Hans-Jürgen |
| collection | DOAJ |
| description | <p>To assess the role of genes required for skin organogenesis, tissue regeneration and homeostasis, we have established in vitro skin equivalents composed of primary cells or cell lines, respectively. In these organotypic cocultures keratinocytes generate a normal epidermis irrespective of the species and tissue origin of fibroblasts. The combination of cells derived from mouse and human tissues facilitates the identification of the origin of compounds involved in epidermal tissue reconstitution and thus the precise analysis of growth regulatory mechanisms. |
| first_indexed | 2024-12-18T05:22:54Z |
| format | Article |
| id | doaj.art-8e00ad2d886e41bf8170ed1b0cd9015d |
| institution | Directory Open Access Journal |
| issn | 1480-9222 |
| language | English |
| last_indexed | 2024-12-18T05:22:54Z |
| publishDate | 2004-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Procedures Online |
| spelling | doaj.art-8e00ad2d886e41bf8170ed1b0cd9015d2022-12-21T21:19:36ZengBMCBiological Procedures Online1480-92222004-01-0161556010.1251/bpo72Organotypic cocultures as skin equivalents: A complex and sophisticated in vitro systemStark Hans-JürgenSzabowski AxelFusenig Norbert E.Maas-Szabowski Nicole<p>To assess the role of genes required for skin organogenesis, tissue regeneration and homeostasis, we have established in vitro skin equivalents composed of primary cells or cell lines, respectively. In these organotypic cocultures keratinocytes generate a normal epidermis irrespective of the species and tissue origin of fibroblasts. The combination of cells derived from mouse and human tissues facilitates the identification of the origin of compounds involved in epidermal tissue reconstitution and thus the precise analysis of growth regulatory mechanisms.http://www.biologicalprocedures.com/bpo/arts/1/72/m72.htmCoculturesKeratinocytesTissue engineering |
| spellingShingle | Stark Hans-Jürgen Szabowski Axel Fusenig Norbert E. Maas-Szabowski Nicole Organotypic cocultures as skin equivalents: A complex and sophisticated in vitro system Biological Procedures Online Cocultures Keratinocytes Tissue engineering |
| title | Organotypic cocultures as skin equivalents: A complex and sophisticated in vitro system |
| title_full | Organotypic cocultures as skin equivalents: A complex and sophisticated in vitro system |
| title_fullStr | Organotypic cocultures as skin equivalents: A complex and sophisticated in vitro system |
| title_full_unstemmed | Organotypic cocultures as skin equivalents: A complex and sophisticated in vitro system |
| title_short | Organotypic cocultures as skin equivalents: A complex and sophisticated in vitro system |
| title_sort | organotypic cocultures as skin equivalents a complex and sophisticated in vitro system |
| topic | Cocultures Keratinocytes Tissue engineering |
| url | http://www.biologicalprocedures.com/bpo/arts/1/72/m72.htm |
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