Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus
Background The major cause of morbidity and mortality in patients with type I diabetes mellitus is premature and extensive artherosclerosis. Carotid intima-media thickness (IMT) is associated with cardivascular risk factors and has been used as a marker of early artherosclerosis process. Objective T...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2016-09-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/522 |
| _version_ | 1818421390921957376 |
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| author | Rubiana Sukardi Bambang Madiyono Sudigdo Sastroasmoro Jose RL Batubara |
| author_facet | Rubiana Sukardi Bambang Madiyono Sudigdo Sastroasmoro Jose RL Batubara |
| author_sort | Rubiana Sukardi |
| collection | DOAJ |
| description | Background The major cause of morbidity and mortality in
patients with type I diabetes mellitus is premature and extensive
artherosclerosis. Carotid intima-media thickness (IMT) is
associated with cardivascular risk factors and has been used as a
marker of early artherosclerosis process.
Objective To determine IMT of carotid artery and its relationship
with duration of diabetes, lipid profiles, and mean HbA 1 level.
Methods A cross-sectional study was conducted on patients
with type 1 DM at the Department of Child Health Cipto
Mangunkusumo Hospital. Ultrasound B-mode imaging was
performed to measure the IMT. Age-matched non-diabtetic
subjects served as controls. Statistical significant was assumed
at P<O.S.
Results The mean IMT values of type I DM patients aged < 12
years, 12-18 years, 18+ years were 0.44 (SD 0.03) mm; 0.46
(SD 0.01) mm; 0.51 (SD 0.01) mm, respectively, which were
significantly greater than those of age-matched non-diabetic
subjects which were 0.39 (SD 0.01), 0.41 (SD 0.01) mm, 0.46
(SD 0.01) mm, respectively. Patients with type I DM had a
higher apolipoprotein-Band HDL cholesterol levels than in non-
diabetic subjects. Multiple regression analysis showed that there
was no relationship between total cholesterol, cholesterol LDL,
chronic hyperglycemia (HbA 1) and IMT. However, IMT in type
I diabetes was linearly related with duration of diabetes .
Conclusion Type I DM patients have greater IMT and higher
mean apolipoprotein B. There is a strong correlation between
IMT and duration of diabetes. |
| first_indexed | 2024-12-14T13:09:36Z |
| format | Article |
| id | doaj.art-8e01d8d4ad3849828d6a019993740da6 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-14T13:09:36Z |
| publishDate | 2016-09-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-8e01d8d4ad3849828d6a019993740da62022-12-21T23:00:13ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-09-014831475110.14238/pi48.3.2008.147-51404Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitusRubiana SukardiBambang MadiyonoSudigdo SastroasmoroJose RL BatubaraBackground The major cause of morbidity and mortality in patients with type I diabetes mellitus is premature and extensive artherosclerosis. Carotid intima-media thickness (IMT) is associated with cardivascular risk factors and has been used as a marker of early artherosclerosis process. Objective To determine IMT of carotid artery and its relationship with duration of diabetes, lipid profiles, and mean HbA 1 level. Methods A cross-sectional study was conducted on patients with type 1 DM at the Department of Child Health Cipto Mangunkusumo Hospital. Ultrasound B-mode imaging was performed to measure the IMT. Age-matched non-diabtetic subjects served as controls. Statistical significant was assumed at P<O.S. Results The mean IMT values of type I DM patients aged < 12 years, 12-18 years, 18+ years were 0.44 (SD 0.03) mm; 0.46 (SD 0.01) mm; 0.51 (SD 0.01) mm, respectively, which were significantly greater than those of age-matched non-diabetic subjects which were 0.39 (SD 0.01), 0.41 (SD 0.01) mm, 0.46 (SD 0.01) mm, respectively. Patients with type I DM had a higher apolipoprotein-Band HDL cholesterol levels than in non- diabetic subjects. Multiple regression analysis showed that there was no relationship between total cholesterol, cholesterol LDL, chronic hyperglycemia (HbA 1) and IMT. However, IMT in type I diabetes was linearly related with duration of diabetes . Conclusion Type I DM patients have greater IMT and higher mean apolipoprotein B. There is a strong correlation between IMT and duration of diabetes.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/522type I DMCarotid artery tunica intima- media thicknessduration of diabeteslipid profile |
| spellingShingle | Rubiana Sukardi Bambang Madiyono Sudigdo Sastroasmoro Jose RL Batubara Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus Paediatrica Indonesiana type I DM Carotid artery tunica intima- media thickness duration of diabetes lipid profile |
| title | Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus |
| title_full | Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus |
| title_fullStr | Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus |
| title_full_unstemmed | Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus |
| title_short | Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus |
| title_sort | relationship between lipid profiles with carotid intima media thickness in children with type i diabetes mellitus |
| topic | type I DM Carotid artery tunica intima- media thickness duration of diabetes lipid profile |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/522 |
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