Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation
Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration us...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Pharmaceutics |
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| Online Access: | http://www.mdpi.com/1999-4923/10/2/70 |
| _version_ | 1818036148428079104 |
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| author | Yuki Shirosaki Motomasa Furuse Takuji Asano Yoshihiko Kinoshita Toshihiko Kuroiwa |
| author_facet | Yuki Shirosaki Motomasa Furuse Takuji Asano Yoshihiko Kinoshita Toshihiko Kuroiwa |
| author_sort | Yuki Shirosaki |
| collection | DOAJ |
| description | Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration using chitosan-siloxane hybrids after long-term implantation (two and three years). After implantation of the hybrids, the surrounding cells migrated and formed fibrous tissues and blood vessels. Then, bone formation occurred from the surrounding blood vessels. Addition of calcium ions and coating with hydroxyapatite improved bone regeneration. Finally, the regenerated tissue area became smaller than the initial hole, and some areas changed to completed bone tissues. |
| first_indexed | 2024-12-10T07:06:21Z |
| format | Article |
| id | doaj.art-8e025b2352074ee9ae7c196b0f95939f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-12-10T07:06:21Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8e025b2352074ee9ae7c196b0f95939f2022-12-22T01:58:11ZengMDPI AGPharmaceutics1999-49232018-06-011027010.3390/pharmaceutics10020070pharmaceutics10020070Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term ImplantationYuki Shirosaki0Motomasa Furuse1Takuji Asano2Yoshihiko Kinoshita3Toshihiko Kuroiwa4Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu 804-8550, JapanDepartment of Neurosurgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, JapanNikkiso Co., Ltd., Ebisu, Shibuya-ku, Tokyo 150-6022, JapanNikkiso Co., Ltd., Ebisu, Shibuya-ku, Tokyo 150-6022, JapanDepartment of Neurosurgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, JapanBurr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration using chitosan-siloxane hybrids after long-term implantation (two and three years). After implantation of the hybrids, the surrounding cells migrated and formed fibrous tissues and blood vessels. Then, bone formation occurred from the surrounding blood vessels. Addition of calcium ions and coating with hydroxyapatite improved bone regeneration. Finally, the regenerated tissue area became smaller than the initial hole, and some areas changed to completed bone tissues.http://www.mdpi.com/1999-4923/10/2/70skull bone regenerationchitosan-siloxane porous hybridlong-term implantation |
| spellingShingle | Yuki Shirosaki Motomasa Furuse Takuji Asano Yoshihiko Kinoshita Toshihiko Kuroiwa Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation Pharmaceutics skull bone regeneration chitosan-siloxane porous hybrid long-term implantation |
| title | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
| title_full | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
| title_fullStr | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
| title_full_unstemmed | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
| title_short | Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation |
| title_sort | skull bone regeneration using chitosan siloxane porous hybrids long term implantation |
| topic | skull bone regeneration chitosan-siloxane porous hybrid long-term implantation |
| url | http://www.mdpi.com/1999-4923/10/2/70 |
| work_keys_str_mv | AT yukishirosaki skullboneregenerationusingchitosansiloxaneporoushybridslongtermimplantation AT motomasafuruse skullboneregenerationusingchitosansiloxaneporoushybridslongtermimplantation AT takujiasano skullboneregenerationusingchitosansiloxaneporoushybridslongtermimplantation AT yoshihikokinoshita skullboneregenerationusingchitosansiloxaneporoushybridslongtermimplantation AT toshihikokuroiwa skullboneregenerationusingchitosansiloxaneporoushybridslongtermimplantation |