Peluang Kejadian Ototoksisitas pada Penggunaan Kanamisin dalam Pengobatan Tuberkulosis Resisten Obat Ganda Selama Satu Bulan
Ototoxic drugs are medicines that cause toxic reactions to structures in the cochlea, vestibule, semicircular canal, and otolith. Kanamycin is a drug used in the treatment of Multidrug Resistant Tuberculosis (MDR TB) and potentially ototoxic. This study aimed to determine the possibility of kanamyci...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2015-12-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/619 |
| _version_ | 1818527298520875008 |
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| author | Lussie Rakhmawati Ratna Anggraeni Agustian Wijana |
| author_facet | Lussie Rakhmawati Ratna Anggraeni Agustian Wijana |
| author_sort | Lussie Rakhmawati |
| collection | DOAJ |
| description | Ototoxic drugs are medicines that cause toxic reactions to structures in the cochlea, vestibule, semicircular canal, and otolith. Kanamycin is a drug used in the treatment of Multidrug Resistant Tuberculosis (MDR TB) and potentially ototoxic. This study aimed to determine the possibility of kanamycin ototoxicity as an initial step of early detection in MDR TB treatment . This study was a descriptive study conducted prospectively and performed in dr. Hasan Sadikin General Hospital Bandung during the period of January–June 2014. The study involved MDR TB patients. Preliminary examinations were performed using pure tone audiometry, tympanometry and DPOAE, which was then followed by further investigations using DPOAE examination every 3 days during the first month of treatment. The results showed cochlear disorders on the right and left ear started to 10,000 Hz frequency on days 19–21, then the frequency of 8,000 Hz on days 25–27. There was a negative relationship between cochlear disorders due to use of kanamycin with age, and no correlation between cochlear disorders with gender and body mass index. In conclusion, possibility of kanamycin ototoxicity in patients with MDR TB begins at the end of the second week, first on high frequency and continues to lower frequency. |
| first_indexed | 2024-12-11T06:34:19Z |
| format | Article |
| id | doaj.art-8e04bf5db7a041d0b35729be83430205 |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-12-11T06:34:19Z |
| publishDate | 2015-12-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-8e04bf5db7a041d0b35729be834302052022-12-22T01:17:25ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232015-12-0147422423010.15395/mkb.v47n4.619Peluang Kejadian Ototoksisitas pada Penggunaan Kanamisin dalam Pengobatan Tuberkulosis Resisten Obat Ganda Selama Satu BulanLussie Rakhmawati0Ratna Anggraeni Agustian1Wijana2Rumah Sakit Siloam Sriwijaya PalembangDepartemen Ilmu Kesehatan Telinga Hidung Tenggorok-Bedah Kepala Leher Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Ilmu Kesehatan Telinga Hidung Tenggorok-Bedah Kepala Leher Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin BandungOtotoxic drugs are medicines that cause toxic reactions to structures in the cochlea, vestibule, semicircular canal, and otolith. Kanamycin is a drug used in the treatment of Multidrug Resistant Tuberculosis (MDR TB) and potentially ototoxic. This study aimed to determine the possibility of kanamycin ototoxicity as an initial step of early detection in MDR TB treatment . This study was a descriptive study conducted prospectively and performed in dr. Hasan Sadikin General Hospital Bandung during the period of January–June 2014. The study involved MDR TB patients. Preliminary examinations were performed using pure tone audiometry, tympanometry and DPOAE, which was then followed by further investigations using DPOAE examination every 3 days during the first month of treatment. The results showed cochlear disorders on the right and left ear started to 10,000 Hz frequency on days 19–21, then the frequency of 8,000 Hz on days 25–27. There was a negative relationship between cochlear disorders due to use of kanamycin with age, and no correlation between cochlear disorders with gender and body mass index. In conclusion, possibility of kanamycin ototoxicity in patients with MDR TB begins at the end of the second week, first on high frequency and continues to lower frequency.http://journal.fk.unpad.ac.id/index.php/mkb/article/view/619Early detectionMDR TBkanamycinototoxic |
| spellingShingle | Lussie Rakhmawati Ratna Anggraeni Agustian Wijana Peluang Kejadian Ototoksisitas pada Penggunaan Kanamisin dalam Pengobatan Tuberkulosis Resisten Obat Ganda Selama Satu Bulan Majalah Kedokteran Bandung Early detection MDR TB kanamycin ototoxic |
| title | Peluang Kejadian Ototoksisitas pada Penggunaan Kanamisin dalam Pengobatan Tuberkulosis Resisten Obat Ganda Selama Satu Bulan |
| title_full | Peluang Kejadian Ototoksisitas pada Penggunaan Kanamisin dalam Pengobatan Tuberkulosis Resisten Obat Ganda Selama Satu Bulan |
| title_fullStr | Peluang Kejadian Ototoksisitas pada Penggunaan Kanamisin dalam Pengobatan Tuberkulosis Resisten Obat Ganda Selama Satu Bulan |
| title_full_unstemmed | Peluang Kejadian Ototoksisitas pada Penggunaan Kanamisin dalam Pengobatan Tuberkulosis Resisten Obat Ganda Selama Satu Bulan |
| title_short | Peluang Kejadian Ototoksisitas pada Penggunaan Kanamisin dalam Pengobatan Tuberkulosis Resisten Obat Ganda Selama Satu Bulan |
| title_sort | peluang kejadian ototoksisitas pada penggunaan kanamisin dalam pengobatan tuberkulosis resisten obat ganda selama satu bulan |
| topic | Early detection MDR TB kanamycin ototoxic |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/619 |
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