EEG microstate analysis in drug-naive patients with panic disorder.
Patients with panic disorder (PD) have a bias to respond to normal stimuli in a fearful way. This may be due to the preactivation of fear-associated networks prior to stimulus perception. Based on EEG, we investigated the difference between patients with PD and normal controls in resting state activ...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829554/?tool=EBI |
| _version_ | 1818718783440683008 |
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| author | Mitsuru Kikuchi Thomas Koenig Toshio Munesue Akira Hanaoka Werner Strik Thomas Dierks Yoshifumi Koshino Yoshio Minabe |
| author_facet | Mitsuru Kikuchi Thomas Koenig Toshio Munesue Akira Hanaoka Werner Strik Thomas Dierks Yoshifumi Koshino Yoshio Minabe |
| author_sort | Mitsuru Kikuchi |
| collection | DOAJ |
| description | Patients with panic disorder (PD) have a bias to respond to normal stimuli in a fearful way. This may be due to the preactivation of fear-associated networks prior to stimulus perception. Based on EEG, we investigated the difference between patients with PD and normal controls in resting state activity using features of transiently stable brain states (microstates). EEGs from 18 drug-naive patients and 18 healthy controls were analyzed. Microstate analysis showed that one class of microstates (with a right-anterior to left-posterior orientation of the mapped field) displayed longer durations and covered more of the total time in the patients than controls. Another microstate class (with a symmetric, anterior-posterior orientation) was observed less frequently in the patients compared to controls. The observation that selected microstate classes differ between patients with PD and controls suggests that specific brain functions are altered already during resting condition. The altered resting state may be the starting point of the observed dysfunctional processing of phobic stimuli. |
| first_indexed | 2024-12-17T19:56:32Z |
| format | Article |
| id | doaj.art-8e052f401bb64f91a34bc0810a7c2141 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T19:56:32Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8e052f401bb64f91a34bc0810a7c21412022-12-21T21:34:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0167e2291210.1371/journal.pone.0022912EEG microstate analysis in drug-naive patients with panic disorder.Mitsuru KikuchiThomas KoenigToshio MunesueAkira HanaokaWerner StrikThomas DierksYoshifumi KoshinoYoshio MinabePatients with panic disorder (PD) have a bias to respond to normal stimuli in a fearful way. This may be due to the preactivation of fear-associated networks prior to stimulus perception. Based on EEG, we investigated the difference between patients with PD and normal controls in resting state activity using features of transiently stable brain states (microstates). EEGs from 18 drug-naive patients and 18 healthy controls were analyzed. Microstate analysis showed that one class of microstates (with a right-anterior to left-posterior orientation of the mapped field) displayed longer durations and covered more of the total time in the patients than controls. Another microstate class (with a symmetric, anterior-posterior orientation) was observed less frequently in the patients compared to controls. The observation that selected microstate classes differ between patients with PD and controls suggests that specific brain functions are altered already during resting condition. The altered resting state may be the starting point of the observed dysfunctional processing of phobic stimuli.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829554/?tool=EBI |
| spellingShingle | Mitsuru Kikuchi Thomas Koenig Toshio Munesue Akira Hanaoka Werner Strik Thomas Dierks Yoshifumi Koshino Yoshio Minabe EEG microstate analysis in drug-naive patients with panic disorder. PLoS ONE |
| title | EEG microstate analysis in drug-naive patients with panic disorder. |
| title_full | EEG microstate analysis in drug-naive patients with panic disorder. |
| title_fullStr | EEG microstate analysis in drug-naive patients with panic disorder. |
| title_full_unstemmed | EEG microstate analysis in drug-naive patients with panic disorder. |
| title_short | EEG microstate analysis in drug-naive patients with panic disorder. |
| title_sort | eeg microstate analysis in drug naive patients with panic disorder |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829554/?tool=EBI |
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