Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis

Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis

Abstract The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United...

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Bibliographic Details
Main Authors: Owen Dean, Seher Anjum, Terri Scott, Lillian Ham, Katherine Traino, Jing Wang, Sally Hunsberger, John H. Powers, Kieren A. Marr, Joseph Snow, Peter R. Williamson
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83176-2
Description
Summary:Abstract The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United States. We identified moderate or severe self-reported impairment in at least one QOL domain in 61% of subjects at least one year following diagnosis. Self-reported cognitive impairment was noted in 52% and sleep disturbance was noted in 55%. This is the first comprehensive study of cross-sectional long-term QOL in previously healthy patients following cryptococcal infection.
ISSN:2045-2322

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