The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling – a possible implication for methamphetamine use?
The human neuronal protein α-synuclein (α-syn) has been linked by a plethora of studies as a causative factor in sporadic Parkinson’s disease (PD). To speed the pace of discovery about the biology and pathobiology of α-syn, organisms such as yeast, worms, and flies have been used to investigate the...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2014-03-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/the-parkinsons-disease-associated-protein-%CE%B1-synuclein-disrupts-stress-signaling-a-possible-implication-for-methamphetamine-use/ |
| _version_ | 1811306878735482880 |
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| author | Shaoxiao Wang Stephan N. Witt |
| author_facet | Shaoxiao Wang Stephan N. Witt |
| author_sort | Shaoxiao Wang |
| collection | DOAJ |
| description | The human neuronal protein α-synuclein (α-syn) has been linked by a plethora of studies as a causative factor in sporadic Parkinson’s disease (PD). To speed the pace of discovery about the biology and pathobiology of α-syn, organisms such as yeast, worms, and flies have been used to investigate the mechanisms by which elevated levels of α-syn are toxic to cells and to screen for drugs and genes that suppress this toxicity. We recently reported [Wang et al. Proc. Natl. Acad. Sci.(2012) 109: 16119–16124] that human α-syn, at high expression levels, disrupts stress-activated signal transduction pathways in both yeast and human neuroblastoma cells. Disruption of these signaling pathways ultimately leads to vulnerability to stress and to cell death. Here we discuss how the disruption of cell signaling by α-syn may have relevance to the parkinsonism that is associated with the abuse of the drug methamphetamine (meth). |
| first_indexed | 2024-04-13T08:53:21Z |
| format | Article |
| id | doaj.art-8e0811f2d65d40828e527608bba0b4df |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-04-13T08:53:21Z |
| publishDate | 2014-03-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-8e0811f2d65d40828e527608bba0b4df2022-12-22T02:53:24ZengShared Science Publishers OGMicrobial Cell2311-26382014-03-011413113210.15698/mic2014.04.137The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling – a possible implication for methamphetamine use?Shaoxiao Wang0Stephan N. Witt1Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, USA.Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, USA.The human neuronal protein α-synuclein (α-syn) has been linked by a plethora of studies as a causative factor in sporadic Parkinson’s disease (PD). To speed the pace of discovery about the biology and pathobiology of α-syn, organisms such as yeast, worms, and flies have been used to investigate the mechanisms by which elevated levels of α-syn are toxic to cells and to screen for drugs and genes that suppress this toxicity. We recently reported [Wang et al. Proc. Natl. Acad. Sci.(2012) 109: 16119–16124] that human α-syn, at high expression levels, disrupts stress-activated signal transduction pathways in both yeast and human neuroblastoma cells. Disruption of these signaling pathways ultimately leads to vulnerability to stress and to cell death. Here we discuss how the disruption of cell signaling by α-syn may have relevance to the parkinsonism that is associated with the abuse of the drug methamphetamine (meth).http://microbialcell.com/researcharticles/the-parkinsons-disease-associated-protein-%CE%B1-synuclein-disrupts-stress-signaling-a-possible-implication-for-methamphetamine-use/α-synucleinmethamphetamineParkinson’s diseasepolo-like kinasesignaling |
| spellingShingle | Shaoxiao Wang Stephan N. Witt The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling – a possible implication for methamphetamine use? Microbial Cell α-synuclein methamphetamine Parkinson’s disease polo-like kinase signaling |
| title | The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling – a possible implication for methamphetamine use? |
| title_full | The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling – a possible implication for methamphetamine use? |
| title_fullStr | The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling – a possible implication for methamphetamine use? |
| title_full_unstemmed | The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling – a possible implication for methamphetamine use? |
| title_short | The Parkinson’s disease-associated protein α-synuclein disrupts stress signaling – a possible implication for methamphetamine use? |
| title_sort | parkinson s disease associated protein α synuclein disrupts stress signaling a possible implication for methamphetamine use |
| topic | α-synuclein methamphetamine Parkinson’s disease polo-like kinase signaling |
| url | http://microbialcell.com/researcharticles/the-parkinsons-disease-associated-protein-%CE%B1-synuclein-disrupts-stress-signaling-a-possible-implication-for-methamphetamine-use/ |
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