Neurotrophin-3 Promotes the Neuronal Differentiation of BMSCs and Improves Cognitive Function in a Rat Model of Alzheimer's Disease

Neurotrophin-3 Promotes the Neuronal Differentiation of BMSCs and Improves Cognitive Function in a Rat Model of Alzheimer's Disease

Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) has the potential to be developed into an effective treatment for neurodegenerative diseases such as Alzheimer's disease (AD). However, the therapeutic effects of BMSCs are limited by their low neural differentiation rate. We...

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Bibliographic Details
Main Authors:	Zhongrui Yan, Xianjing Shi, Hui Wang, Cuiping Si, Qian Liu, Yifeng Du
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	bone marrow-derived mesenchymal stem cells (BMSCs) neurotrophin-3 (NT-3) neuronal differentiation Wnt/β-catenin Alzheimer's disease 3
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2021.629356/full

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