Acute Kidney Injury due to Rhabdomyolysis
Rhabdomyolysis is a clinical and biochemical syndrome that occurs when skeletal muscle cells disrupt and release creatine phosphokinase (CK), lactate dehydrogenase (LDH), and myoglobin into the interstitial space and plasma. The main causes of rhabdomyolysis include direct muscular injury, strenuous...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2008-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Subjects: | |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2008;volume=19;issue=5;spage=721;epage=729;aulast=Lima |
| _version_ | 1818518062420197376 |
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| author | Lima Rafael Siqueira da Silva Junior Geraldo Liborio Alexandre Daher Elizabeth |
| author_facet | Lima Rafael Siqueira da Silva Junior Geraldo Liborio Alexandre Daher Elizabeth |
| author_sort | Lima Rafael Siqueira |
| collection | DOAJ |
| description | Rhabdomyolysis is a clinical and biochemical syndrome that occurs when skeletal muscle cells disrupt and release creatine phosphokinase (CK), lactate dehydrogenase (LDH), and myoglobin into the interstitial space and plasma. The main causes of rhabdomyolysis include direct muscular injury, strenuous exercise, drugs, toxins, infections, hyperthermia, seizures, meta-bolic and/or electrolyte abnormalities, and endocrinopathies. Acute kidney injury (AKI) occurs in 33-50% of patients with rhabdomyolysis. The main pathophysiological mechanisms of renal injury are renal vasoconstriction, intraluminal cast formation, and direct myoglobin toxicity. Rhabdo-myolysis can be asymptomatic, present with mild symptoms such as elevation of muscular en-zymes, or manifest as a severe syndrome with AKI and high mortality. Serum CK five times higher than the normal value usually confirms rhabdomyolysis. Early diagnosis and saline volume expansion may reduce the risk of AKI. Further studies are necessary to establish the importance of bicarbonate and mannitol in the prevention of AKI due to rhabdomyolysis. |
| first_indexed | 2024-12-11T01:04:58Z |
| format | Article |
| id | doaj.art-8e0996486cc54a1ebc94035542b0ee8d |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-11T01:04:58Z |
| publishDate | 2008-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-8e0996486cc54a1ebc94035542b0ee8d2022-12-22T01:26:13ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422008-01-01195721729Acute Kidney Injury due to RhabdomyolysisLima Rafael Siqueirada Silva Junior GeraldoLiborio AlexandreDaher ElizabethRhabdomyolysis is a clinical and biochemical syndrome that occurs when skeletal muscle cells disrupt and release creatine phosphokinase (CK), lactate dehydrogenase (LDH), and myoglobin into the interstitial space and plasma. The main causes of rhabdomyolysis include direct muscular injury, strenuous exercise, drugs, toxins, infections, hyperthermia, seizures, meta-bolic and/or electrolyte abnormalities, and endocrinopathies. Acute kidney injury (AKI) occurs in 33-50% of patients with rhabdomyolysis. The main pathophysiological mechanisms of renal injury are renal vasoconstriction, intraluminal cast formation, and direct myoglobin toxicity. Rhabdo-myolysis can be asymptomatic, present with mild symptoms such as elevation of muscular en-zymes, or manifest as a severe syndrome with AKI and high mortality. Serum CK five times higher than the normal value usually confirms rhabdomyolysis. Early diagnosis and saline volume expansion may reduce the risk of AKI. Further studies are necessary to establish the importance of bicarbonate and mannitol in the prevention of AKI due to rhabdomyolysis.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2008;volume=19;issue=5;spage=721;epage=729;aulast=LimaRhabdomyolysisMyoglobinAcute kidney injuryPathophysiologyTreatment |
| spellingShingle | Lima Rafael Siqueira da Silva Junior Geraldo Liborio Alexandre Daher Elizabeth Acute Kidney Injury due to Rhabdomyolysis Saudi Journal of Kidney Diseases and Transplantation Rhabdomyolysis Myoglobin Acute kidney injury Pathophysiology Treatment |
| title | Acute Kidney Injury due to Rhabdomyolysis |
| title_full | Acute Kidney Injury due to Rhabdomyolysis |
| title_fullStr | Acute Kidney Injury due to Rhabdomyolysis |
| title_full_unstemmed | Acute Kidney Injury due to Rhabdomyolysis |
| title_short | Acute Kidney Injury due to Rhabdomyolysis |
| title_sort | acute kidney injury due to rhabdomyolysis |
| topic | Rhabdomyolysis Myoglobin Acute kidney injury Pathophysiology Treatment |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2008;volume=19;issue=5;spage=721;epage=729;aulast=Lima |
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