Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer
OBJECTIVES: This study sought to determine the clinical and pathological factors associated with perioperative morbidity, mortality and oncological outcomes after multivisceral en bloc resection in patients with colorectal cancer. METHODS: Between January 2009 and February 2014, 105 patients with p...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
|
| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017000500258&lng=en&tlng=en |
| _version_ | 1811329523846742016 |
|---|---|
| author | Caio Sergio Rizkallah Nahas Sergio Carlos Nahas Ulysses Ribeiro-Junior Leonardo Bustamante-Lopez Carlos Frederico Sparapan Marques Rodrigo Ambar Pinto Antonio Rocco Imperiale Guilherme Cutait Cotti William Carlos Nahas Daher Cezar Chade Dariane Sampaio Piato Fabio Busnardo Ivan Cecconello |
| author_facet | Caio Sergio Rizkallah Nahas Sergio Carlos Nahas Ulysses Ribeiro-Junior Leonardo Bustamante-Lopez Carlos Frederico Sparapan Marques Rodrigo Ambar Pinto Antonio Rocco Imperiale Guilherme Cutait Cotti William Carlos Nahas Daher Cezar Chade Dariane Sampaio Piato Fabio Busnardo Ivan Cecconello |
| author_sort | Caio Sergio Rizkallah Nahas |
| collection | DOAJ |
| description | OBJECTIVES: This study sought to determine the clinical and pathological factors associated with perioperative morbidity, mortality and oncological outcomes after multivisceral en bloc resection in patients with colorectal cancer. METHODS: Between January 2009 and February 2014, 105 patients with primary colorectal cancer selected for multivisceral resection were identified from a prospective database. Clinical and pathological factors, perioperative morbidity and mortality and outcomes were obtained from medical records. Estimated local recurrence and overall survival were compared using the log-rank method, and Cox regression analysis was used to determine the independence of the studied parameters. ClinicalTrials.gov: NCT02859155. RESULTS: The median age of the patients was 60 (range 23-86) years, 66.7% were female, 80% of tumors were located in the rectum, 11.4% had stage-IV disease, and 54.3% received neoadjuvant chemoradiotherapy. The organs most frequently resected were ovaries and annexes (37%). Additionally, 30.5% of patients received abdominoperineal resection. Invasion of other organs was confirmed histologically in 53.5% of patients, and R0 resection was obtained in 72% of patients. The overall morbidity rate of patients in this study was 37.1%. Ureter resection and intraoperative blood transfusion were independently associated with an increased number of complications. The 30-day postoperative mortality rate was 1.9%. After 27 (range 5-57) months of follow-up, the mortality and local recurrence rates were 23% and 15%, respectively. Positive margins were associated with a higher recurrence rate. Positive margins, lymph node involvement, stage III/IV disease, and stage IV disease alone were associated with lower overall survival rates. On multivariate analysis, the only factor associated with reduced survival was lymph node involvement. CONCLUSIONS: Multivisceral en bloc resection for primary colorectal cancer can be performed with acceptable rates of morbidity and mortality and may lead to favorable oncological outcomes. |
| first_indexed | 2024-04-13T15:45:30Z |
| format | Article |
| id | doaj.art-8e0acc33f45046c6b46332749fb8e9e5 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T15:45:30Z |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-8e0acc33f45046c6b46332749fb8e9e52022-12-22T02:40:59ZengElsevier EspañaClinics1980-532272525826410.6061/clinics/2017(05)01S1807-59322017000500258Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancerCaio Sergio Rizkallah NahasSergio Carlos NahasUlysses Ribeiro-JuniorLeonardo Bustamante-LopezCarlos Frederico Sparapan MarquesRodrigo Ambar PintoAntonio Rocco ImperialeGuilherme Cutait CottiWilliam Carlos NahasDaher Cezar ChadeDariane Sampaio PiatoFabio BusnardoIvan CecconelloOBJECTIVES: This study sought to determine the clinical and pathological factors associated with perioperative morbidity, mortality and oncological outcomes after multivisceral en bloc resection in patients with colorectal cancer. METHODS: Between January 2009 and February 2014, 105 patients with primary colorectal cancer selected for multivisceral resection were identified from a prospective database. Clinical and pathological factors, perioperative morbidity and mortality and outcomes were obtained from medical records. Estimated local recurrence and overall survival were compared using the log-rank method, and Cox regression analysis was used to determine the independence of the studied parameters. ClinicalTrials.gov: NCT02859155. RESULTS: The median age of the patients was 60 (range 23-86) years, 66.7% were female, 80% of tumors were located in the rectum, 11.4% had stage-IV disease, and 54.3% received neoadjuvant chemoradiotherapy. The organs most frequently resected were ovaries and annexes (37%). Additionally, 30.5% of patients received abdominoperineal resection. Invasion of other organs was confirmed histologically in 53.5% of patients, and R0 resection was obtained in 72% of patients. The overall morbidity rate of patients in this study was 37.1%. Ureter resection and intraoperative blood transfusion were independently associated with an increased number of complications. The 30-day postoperative mortality rate was 1.9%. After 27 (range 5-57) months of follow-up, the mortality and local recurrence rates were 23% and 15%, respectively. Positive margins were associated with a higher recurrence rate. Positive margins, lymph node involvement, stage III/IV disease, and stage IV disease alone were associated with lower overall survival rates. On multivariate analysis, the only factor associated with reduced survival was lymph node involvement. CONCLUSIONS: Multivisceral en bloc resection for primary colorectal cancer can be performed with acceptable rates of morbidity and mortality and may lead to favorable oncological outcomes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017000500258&lng=en&tlng=enColorectal CancerSurvivalRecurrence |
| spellingShingle | Caio Sergio Rizkallah Nahas Sergio Carlos Nahas Ulysses Ribeiro-Junior Leonardo Bustamante-Lopez Carlos Frederico Sparapan Marques Rodrigo Ambar Pinto Antonio Rocco Imperiale Guilherme Cutait Cotti William Carlos Nahas Daher Cezar Chade Dariane Sampaio Piato Fabio Busnardo Ivan Cecconello Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer Clinics Colorectal Cancer Survival Recurrence |
| title | Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer |
| title_full | Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer |
| title_fullStr | Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer |
| title_full_unstemmed | Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer |
| title_short | Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer |
| title_sort | prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer |
| topic | Colorectal Cancer Survival Recurrence |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017000500258&lng=en&tlng=en |
| work_keys_str_mv | AT caiosergiorizkallahnahas prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT sergiocarlosnahas prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT ulyssesribeirojunior prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT leonardobustamantelopez prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT carlosfredericosparapanmarques prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT rodrigoambarpinto prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT antonioroccoimperiale prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT guilhermecutaitcotti prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT williamcarlosnahas prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT dahercezarchade prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT darianesampaiopiato prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT fabiobusnardo prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer AT ivancecconello prognosticfactorsaffectingoutcomesinmultivisceralenblocresectionforcolorectalcancer |