In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation
Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/1/29 |
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| author | Seung Kyun Yoon Jin Ho Yang Hyun Tae Lim Young-Wook Chang Muhammad Ayyoob Xin Yang Young Jun Kim Han-Seung Ko Jae Young Jho Dong June Chung |
| author_facet | Seung Kyun Yoon Jin Ho Yang Hyun Tae Lim Young-Wook Chang Muhammad Ayyoob Xin Yang Young Jun Kim Han-Seung Ko Jae Young Jho Dong June Chung |
| author_sort | Seung Kyun Yoon |
| collection | DOAJ |
| description | Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials. |
| first_indexed | 2024-03-10T13:49:34Z |
| format | Article |
| id | doaj.art-8e0b6948110a4c3f97a86ebe6573d958 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T13:49:34Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-8e0b6948110a4c3f97a86ebe6573d9582023-11-21T02:19:53ZengMDPI AGPolymers2073-43602020-12-011312910.3390/polym13010029In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal FixationSeung Kyun Yoon0Jin Ho Yang1Hyun Tae Lim2Young-Wook Chang3Muhammad Ayyoob4Xin Yang5Young Jun Kim6Han-Seung Ko7Jae Young Jho8Dong June Chung9School of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, KoreaDepartment of Materials & Chemical Engineering, Hanyang University, 55 Hanyangdaehak-Ro, Sangnok-Gu, Ansan, Gyeonggi 15588, KoreaDepartment of Materials & Chemical Engineering, Hanyang University, 55 Hanyangdaehak-Ro, Sangnok-Gu, Ansan, Gyeonggi 15588, KoreaDepartment of Materials & Chemical Engineering, Hanyang University, 55 Hanyangdaehak-Ro, Sangnok-Gu, Ansan, Gyeonggi 15588, KoreaSchool of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, KoreaSchool of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, KoreaSchool of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, KoreaSchool of Chemical and Biological Engineering, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul 08826, KoreaSchool of Chemical and Biological Engineering, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul 08826, KoreaSchool of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, KoreaHerein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.https://www.mdpi.com/2073-4360/13/1/29PGA–PLA block copolymerbioresorbablecompositein vivo degradation testMTT assay |
| spellingShingle | Seung Kyun Yoon Jin Ho Yang Hyun Tae Lim Young-Wook Chang Muhammad Ayyoob Xin Yang Young Jun Kim Han-Seung Ko Jae Young Jho Dong June Chung In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation Polymers PGA–PLA block copolymer bioresorbable composite in vivo degradation test MTT assay |
| title | In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation |
| title_full | In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation |
| title_fullStr | In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation |
| title_full_unstemmed | In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation |
| title_short | In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation |
| title_sort | in vitro and in vivo biosafety analysis of resorbable polyglycolic acid polylactic acid block copolymer composites for spinal fixation |
| topic | PGA–PLA block copolymer bioresorbable composite in vivo degradation test MTT assay |
| url | https://www.mdpi.com/2073-4360/13/1/29 |
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