Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes

Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes

Impaired beta-cell insulin secretion is a key pathological feature of type 2 diabetes. Here, the authors describe metabolic stress induced lysosomal degradation of newly formed insulin granules, independent of macroautophagy, as a potential mechanism for beta-cell dysfunction.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Adrien Pasquier, Kevin Vivot, Eric Erbs, Coralie Spiegelhalter, Zhirong Zhang, Victor Aubert, Zengzhen Liu, Meryem Senkara, Elisa Maillard, Michel Pinget, Julie Kerr-Conte, François Pattou, Gilbert Marciniak, Axel Ganzhorn, Paolo Ronchi, Nicole L. Schieber, Yannick Schwab, Paul Saftig, Alexander Goginashvili, Romeo Ricci
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: Nature Portfolio 2019-07-01
Σειρά:Nature Communications
Διαθέσιμο Online:https://doi.org/10.1038/s41467-019-11170-4
Περιγραφή
Περίληψη:Impaired beta-cell insulin secretion is a key pathological feature of type 2 diabetes. Here, the authors describe metabolic stress induced lysosomal degradation of newly formed insulin granules, independent of macroautophagy, as a potential mechanism for beta-cell dysfunction.
ISSN:2041-1723

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