Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
Impaired beta-cell insulin secretion is a key pathological feature of type 2 diabetes. Here, the authors describe metabolic stress induced lysosomal degradation of newly formed insulin granules, independent of macroautophagy, as a potential mechanism for beta-cell dysfunction.
Huvudupphovsmän: | , , , , , , , , , , , , , , , , , , , |
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Materialtyp: | Artikel |
Språk: | English |
Publicerad: |
Nature Portfolio
2019-07-01
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Serie: | Nature Communications |
Länkar: | https://doi.org/10.1038/s41467-019-11170-4 |