Design principles of a microtubule polymerase

Design principles of a microtubule polymerase

Stu2/XMAP215 microtubule polymerases use multiple tubulin-binding TOG domains and a lattice-binding basic region to processively promote faster elongation. How the domain composition and organization of these proteins dictate polymerase activity, end localization, and processivity is unknown. We sho...

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Bibliographic Details
Main Authors: Elisabeth A Geyer, Matthew P Miller, Chad A Brautigam, Sue Biggins, Luke M Rice
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
Microtubule dynamics
Microtubule polymerase
In vitro reconstitution
Online Access:https://elifesciences.org/articles/34574

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