Rationale and design of the application value of Beijing Vascular Health Stratification (BVHS): predictive value of combined assessment of vascular structure and function for cardiovascular events in general Chinese population
Abstract Background Vascular endothelial dysfunction, arteriosclerosis and atherosclerotic plaque are well-known risk factors for cardiovascular disease (CVD). Studies on vascular health markers have been well-established, however, there is still a lack of related research on combined vascular struc...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-021-02289-8 |
| _version_ | 1819043378673745920 |
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| author | Huan Liu Xiaohua Zhou Jinbo Liu Wei Huang Na Zhao Hongyu Wang |
| author_facet | Huan Liu Xiaohua Zhou Jinbo Liu Wei Huang Na Zhao Hongyu Wang |
| author_sort | Huan Liu |
| collection | DOAJ |
| description | Abstract Background Vascular endothelial dysfunction, arteriosclerosis and atherosclerotic plaque are well-known risk factors for cardiovascular disease (CVD). Studies on vascular health markers have been well-established, however, there is still a lack of related research on combined vascular structure and function indicators. Method Beijing vascular health stratification (BVHS) is an evaluation system aiming at vascular health, combined the endothelial function, arteriosclerosis, atherosclerotic plaque and vascular lumen stenosis to comprehensively assess the vascular health and grade it. This study will explore the predictive value of the combined evaluation of vascular structure and function for cardiovascular events and assess the predictive value of BVHS and compare it with the existing risk assessment systems. A total of 1500 subjects will be enrolled into the prospective cohort study from a community and will be followed up for at least 3 years from July 1, 2020 to June 30, 2023. Subjects aged 40 or above, without coronary heart disease, stroke or peripheral artery disease, with written informed consent will be included; subjects with end-stage hepatorenal diseases (uremia, renal failure, cirrhosis, liver failure), mental disorders or cognitive disorders, with any other factors that the researcher thinks are not suitable for the study will be excluded. Traditional cardiovascular risk factors will be collected as adjusted confounders. Discussion BVHS is a potential and scientific vascular health evaluation system. The study will be the first to grade vascular health by combing various vascular indicators and explore the prediction value and compare with other risk prediction system in general Chinese population. Trial registration: The trial is registered on http://www.chictr.org.cn/ (ChiCTR2000034085). |
| first_indexed | 2024-12-21T09:55:50Z |
| format | Article |
| id | doaj.art-8e0fadb2e1cc413696597d7956f465f0 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-21T09:55:50Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-8e0fadb2e1cc413696597d7956f465f02022-12-21T19:08:04ZengBMCBMC Cardiovascular Disorders1471-22612021-10-012111910.1186/s12872-021-02289-8Rationale and design of the application value of Beijing Vascular Health Stratification (BVHS): predictive value of combined assessment of vascular structure and function for cardiovascular events in general Chinese populationHuan Liu0Xiaohua Zhou1Jinbo Liu2Wei Huang3Na Zhao4Hongyu Wang5Vascular Medicine Center, Peking University Shougang HospitalDepartment of Biostatistics and Beijing International Center for Mathematical Research, Peking UniversityVascular Medicine Center, Peking University Shougang HospitalVascular Medicine Center, Peking University Shougang HospitalVascular Medicine Center, Peking University Shougang HospitalVascular Medicine Center, Peking University Shougang HospitalAbstract Background Vascular endothelial dysfunction, arteriosclerosis and atherosclerotic plaque are well-known risk factors for cardiovascular disease (CVD). Studies on vascular health markers have been well-established, however, there is still a lack of related research on combined vascular structure and function indicators. Method Beijing vascular health stratification (BVHS) is an evaluation system aiming at vascular health, combined the endothelial function, arteriosclerosis, atherosclerotic plaque and vascular lumen stenosis to comprehensively assess the vascular health and grade it. This study will explore the predictive value of the combined evaluation of vascular structure and function for cardiovascular events and assess the predictive value of BVHS and compare it with the existing risk assessment systems. A total of 1500 subjects will be enrolled into the prospective cohort study from a community and will be followed up for at least 3 years from July 1, 2020 to June 30, 2023. Subjects aged 40 or above, without coronary heart disease, stroke or peripheral artery disease, with written informed consent will be included; subjects with end-stage hepatorenal diseases (uremia, renal failure, cirrhosis, liver failure), mental disorders or cognitive disorders, with any other factors that the researcher thinks are not suitable for the study will be excluded. Traditional cardiovascular risk factors will be collected as adjusted confounders. Discussion BVHS is a potential and scientific vascular health evaluation system. The study will be the first to grade vascular health by combing various vascular indicators and explore the prediction value and compare with other risk prediction system in general Chinese population. Trial registration: The trial is registered on http://www.chictr.org.cn/ (ChiCTR2000034085).https://doi.org/10.1186/s12872-021-02289-8Beijing Vascular Health StratificationVascular healthCardiovascular diseaseRisk assessmentPrediction |
| spellingShingle | Huan Liu Xiaohua Zhou Jinbo Liu Wei Huang Na Zhao Hongyu Wang Rationale and design of the application value of Beijing Vascular Health Stratification (BVHS): predictive value of combined assessment of vascular structure and function for cardiovascular events in general Chinese population BMC Cardiovascular Disorders Beijing Vascular Health Stratification Vascular health Cardiovascular disease Risk assessment Prediction |
| title | Rationale and design of the application value of Beijing Vascular Health Stratification (BVHS): predictive value of combined assessment of vascular structure and function for cardiovascular events in general Chinese population |
| title_full | Rationale and design of the application value of Beijing Vascular Health Stratification (BVHS): predictive value of combined assessment of vascular structure and function for cardiovascular events in general Chinese population |
| title_fullStr | Rationale and design of the application value of Beijing Vascular Health Stratification (BVHS): predictive value of combined assessment of vascular structure and function for cardiovascular events in general Chinese population |
| title_full_unstemmed | Rationale and design of the application value of Beijing Vascular Health Stratification (BVHS): predictive value of combined assessment of vascular structure and function for cardiovascular events in general Chinese population |
| title_short | Rationale and design of the application value of Beijing Vascular Health Stratification (BVHS): predictive value of combined assessment of vascular structure and function for cardiovascular events in general Chinese population |
| title_sort | rationale and design of the application value of beijing vascular health stratification bvhs predictive value of combined assessment of vascular structure and function for cardiovascular events in general chinese population |
| topic | Beijing Vascular Health Stratification Vascular health Cardiovascular disease Risk assessment Prediction |
| url | https://doi.org/10.1186/s12872-021-02289-8 |
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