Glioblastoma Cells Counteract PARP Inhibition through Pro-Survival Induction of Lipid Droplets Synthesis and Utilization

Glioblastoma Cells Counteract PARP Inhibition through Pro-Survival Induction of Lipid Droplets Synthesis and Utilization

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Poly (ADP-ribose) polymerase inhibitors (PARPi) represent a new class of anti-neoplastic drugs. In the current study, we have characterized the mechanism by which glioblastoma cells evade the effect of PAR...

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Bibliographic Details
Main Authors: Jara Majuelos-Melguizo, José Manuel Rodríguez-Vargas, Nuria Martínez-López, Daniel Delgado-Bellido, Ángel García-Díaz, Víctor J. Yuste, Marina García-Macía, Laura M. López, Rajat Singh, F. J. Oliver
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
glioblastoma stem cells
PARP inhibitors
lipophagy
lipid droplets
Acyl-coA-carboxylase
metabolic adaptation
Online Access:https://www.mdpi.com/2072-6694/14/3/726

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https://www.mdpi.com/2072-6694/14/3/726

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