The ‘communicatome’ of pregnancy: spotlight on cellular and extravesicular chimerism
Abstract Communication via biological mediators between mother and fetus are key to reproductive success and offspring’s future health. The repertoire of mediators coding signals between mother and fetus is broad and includes soluble factors, membrane-bound particles and immune as well as non-immune...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2024-03-01
|
| Series: | EMBO Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s44321-024-00045-x |
| _version_ | 1797199274330554368 |
|---|---|
| author | Isabel Graf Christopher Urbschat Petra C Arck |
| author_facet | Isabel Graf Christopher Urbschat Petra C Arck |
| author_sort | Isabel Graf |
| collection | DOAJ |
| description | Abstract Communication via biological mediators between mother and fetus are key to reproductive success and offspring’s future health. The repertoire of mediators coding signals between mother and fetus is broad and includes soluble factors, membrane-bound particles and immune as well as non-immune cells. Based on the emergence of technological advancements over the last years, considerable progress has been made toward deciphering the “communicatome” between fetus and mother during pregnancy and even after birth. In this context, pregnancy-associated chimerism has sparked the attention among immunologists, since chimeric cells—although low in number—are maintained in the allogeneic host (mother or fetus) for years after birth. Other non-cellular structures of chimerism, e.g. extracellular vesicles (EVs), are increasingly recognized as modulators of pregnancy outcome and offspring’s health. We here discuss the origin, distribution and function of pregnancy-acquired microchimerism and chimeric EVs in mother and offspring. We also highlight the pioneering concept of maternal microchimeric cell-derived EVs in offspring. Such insights expand the understanding of pregnancy-associated health or disease risks in mother and offspring. |
| first_indexed | 2024-04-24T07:13:09Z |
| format | Article |
| id | doaj.art-8e10a3a52c6a46418776cb7240d6f5f0 |
| institution | Directory Open Access Journal |
| issn | 1757-4684 |
| language | English |
| last_indexed | 2024-04-24T07:13:09Z |
| publishDate | 2024-03-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-8e10a3a52c6a46418776cb7240d6f5f02024-04-21T11:26:43ZengSpringer NatureEMBO Molecular Medicine1757-46842024-03-0116470071410.1038/s44321-024-00045-xThe ‘communicatome’ of pregnancy: spotlight on cellular and extravesicular chimerismIsabel Graf0Christopher Urbschat1Petra C Arck2Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-EppendorfDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-EppendorfDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-EppendorfAbstract Communication via biological mediators between mother and fetus are key to reproductive success and offspring’s future health. The repertoire of mediators coding signals between mother and fetus is broad and includes soluble factors, membrane-bound particles and immune as well as non-immune cells. Based on the emergence of technological advancements over the last years, considerable progress has been made toward deciphering the “communicatome” between fetus and mother during pregnancy and even after birth. In this context, pregnancy-associated chimerism has sparked the attention among immunologists, since chimeric cells—although low in number—are maintained in the allogeneic host (mother or fetus) for years after birth. Other non-cellular structures of chimerism, e.g. extracellular vesicles (EVs), are increasingly recognized as modulators of pregnancy outcome and offspring’s health. We here discuss the origin, distribution and function of pregnancy-acquired microchimerism and chimeric EVs in mother and offspring. We also highlight the pioneering concept of maternal microchimeric cell-derived EVs in offspring. Such insights expand the understanding of pregnancy-associated health or disease risks in mother and offspring.https://doi.org/10.1038/s44321-024-00045-xMicrochimerismPregnancyExtracellular VesiclesFeto-maternal Communication |
| spellingShingle | Isabel Graf Christopher Urbschat Petra C Arck The ‘communicatome’ of pregnancy: spotlight on cellular and extravesicular chimerism EMBO Molecular Medicine Microchimerism Pregnancy Extracellular Vesicles Feto-maternal Communication |
| title | The ‘communicatome’ of pregnancy: spotlight on cellular and extravesicular chimerism |
| title_full | The ‘communicatome’ of pregnancy: spotlight on cellular and extravesicular chimerism |
| title_fullStr | The ‘communicatome’ of pregnancy: spotlight on cellular and extravesicular chimerism |
| title_full_unstemmed | The ‘communicatome’ of pregnancy: spotlight on cellular and extravesicular chimerism |
| title_short | The ‘communicatome’ of pregnancy: spotlight on cellular and extravesicular chimerism |
| title_sort | communicatome of pregnancy spotlight on cellular and extravesicular chimerism |
| topic | Microchimerism Pregnancy Extracellular Vesicles Feto-maternal Communication |
| url | https://doi.org/10.1038/s44321-024-00045-x |
| work_keys_str_mv | AT isabelgraf thecommunicatomeofpregnancyspotlightoncellularandextravesicularchimerism AT christopherurbschat thecommunicatomeofpregnancyspotlightoncellularandextravesicularchimerism AT petracarck thecommunicatomeofpregnancyspotlightoncellularandextravesicularchimerism AT isabelgraf communicatomeofpregnancyspotlightoncellularandextravesicularchimerism AT christopherurbschat communicatomeofpregnancyspotlightoncellularandextravesicularchimerism AT petracarck communicatomeofpregnancyspotlightoncellularandextravesicularchimerism |