Clinically node-negative invasive lobular carcinoma of the breast showing multiple lymph node metastases
A 73-year-old woman was pointed out of her right breast tumor on screening computed tomography (CT). Mammography showed distortion of the mammary gland and skin retraction. Ultrasound (US) showed an irregular tumor with hyperechoic haloes adjacent to the anterior tumor borders. Neither lymphadenopat...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-05-01
|
| Series: | Radiology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043324001006 |
| _version_ | 1827321757632036864 |
|---|---|
| author | Yurie Kitano Shoji Oura |
| author_facet | Yurie Kitano Shoji Oura |
| author_sort | Yurie Kitano |
| collection | DOAJ |
| description | A 73-year-old woman was pointed out of her right breast tumor on screening computed tomography (CT). Mammography showed distortion of the mammary gland and skin retraction. Ultrasound (US) showed an irregular tumor with hyperechoic haloes adjacent to the anterior tumor borders. Neither lymphadenopathy nor image findings suggesting lymph node metastasis were detected on US and CT. Core needle biopsy pathologically showed the tumor to be invasive lobular carcinoma. Under the preoperative diagnosis of node-negative breast cancer, the patient underwent mastectomy and sentinel node biopsy. Due to no sentinel node detection, a small but hard lymph node was identified and submitted for frozen section as a sampling node. After confirming the lymph node metastasis on frozen section, axillary lymph node dissection revealed 12 lymph node metastases. Postoperative pathological study showed cancer cell infiltration to the dermis near the nipple-areolar complex. In addition, immmunostaining showed the tumor to have low proliferative biology, i.e., Ki-67 labelling index of 10%. Breast surgeons should note that indolent invasive lobular carcinoma with cancer cell infiltration to the skin near the nipple-areolar complex can have multiple lymph node metastases even though showing neither lymphadenopathy nor image findings suggesting lymph node metastasis. |
| first_indexed | 2024-03-07T19:42:38Z |
| format | Article |
| id | doaj.art-8e141cf5f5d64623b3f41f98f7782438 |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-04-25T01:12:39Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-8e141cf5f5d64623b3f41f98f77824382024-03-10T05:11:53ZengElsevierRadiology Case Reports1930-04332024-05-0119519261929Clinically node-negative invasive lobular carcinoma of the breast showing multiple lymph node metastasesYurie Kitano0Shoji Oura1Department of Surgery, Kishiwada Tokushukai Hospital 4-27-1, Kamori-cho, Kishiwada-city, Osaka, JapanCorresponding author.; Department of Surgery, Kishiwada Tokushukai Hospital 4-27-1, Kamori-cho, Kishiwada-city, Osaka, JapanA 73-year-old woman was pointed out of her right breast tumor on screening computed tomography (CT). Mammography showed distortion of the mammary gland and skin retraction. Ultrasound (US) showed an irregular tumor with hyperechoic haloes adjacent to the anterior tumor borders. Neither lymphadenopathy nor image findings suggesting lymph node metastasis were detected on US and CT. Core needle biopsy pathologically showed the tumor to be invasive lobular carcinoma. Under the preoperative diagnosis of node-negative breast cancer, the patient underwent mastectomy and sentinel node biopsy. Due to no sentinel node detection, a small but hard lymph node was identified and submitted for frozen section as a sampling node. After confirming the lymph node metastasis on frozen section, axillary lymph node dissection revealed 12 lymph node metastases. Postoperative pathological study showed cancer cell infiltration to the dermis near the nipple-areolar complex. In addition, immmunostaining showed the tumor to have low proliferative biology, i.e., Ki-67 labelling index of 10%. Breast surgeons should note that indolent invasive lobular carcinoma with cancer cell infiltration to the skin near the nipple-areolar complex can have multiple lymph node metastases even though showing neither lymphadenopathy nor image findings suggesting lymph node metastasis.http://www.sciencedirect.com/science/article/pii/S1930043324001006Breast cancerInvasive lobular carcinomaLow Ki-67 labelling indexNipple-areolar complexSkin infiltration |
| spellingShingle | Yurie Kitano Shoji Oura Clinically node-negative invasive lobular carcinoma of the breast showing multiple lymph node metastases Radiology Case Reports Breast cancer Invasive lobular carcinoma Low Ki-67 labelling index Nipple-areolar complex Skin infiltration |
| title | Clinically node-negative invasive lobular carcinoma of the breast showing multiple lymph node metastases |
| title_full | Clinically node-negative invasive lobular carcinoma of the breast showing multiple lymph node metastases |
| title_fullStr | Clinically node-negative invasive lobular carcinoma of the breast showing multiple lymph node metastases |
| title_full_unstemmed | Clinically node-negative invasive lobular carcinoma of the breast showing multiple lymph node metastases |
| title_short | Clinically node-negative invasive lobular carcinoma of the breast showing multiple lymph node metastases |
| title_sort | clinically node negative invasive lobular carcinoma of the breast showing multiple lymph node metastases |
| topic | Breast cancer Invasive lobular carcinoma Low Ki-67 labelling index Nipple-areolar complex Skin infiltration |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324001006 |
| work_keys_str_mv | AT yuriekitano clinicallynodenegativeinvasivelobularcarcinomaofthebreastshowingmultiplelymphnodemetastases AT shojioura clinicallynodenegativeinvasivelobularcarcinomaofthebreastshowingmultiplelymphnodemetastases |