Exercise-induced desaturation in patients with chronic obstructive pulmonary disease on six-minute walk test
Background and Objectives: Exercise-induced desaturation (EID) is associated with increased mortality in chronic obstructive pulmonary disease (COPD). However, the relationship of EID with anthropometric and clinical parameters of resting pulmonary function test and six-minute walk test (6MWT) in CO...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Lung India |
| Subjects: | |
| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2015;volume=32;issue=4;spage=320;epage=325;aulast=Dogra |
| _version_ | 1818281199935684608 |
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| author | Archana Chauhan Dogra Urmil Gupta Malay Sarkar Anita Padam |
| author_facet | Archana Chauhan Dogra Urmil Gupta Malay Sarkar Anita Padam |
| author_sort | Archana Chauhan Dogra |
| collection | DOAJ |
| description | Background and Objectives: Exercise-induced desaturation (EID) is associated with increased mortality in chronic obstructive pulmonary disease (COPD). However, the relationship of EID with anthropometric and clinical parameters of resting pulmonary function test and six-minute walk test (6MWT) in COPD remains unclear. The study was designed to assess the correlate of EID and to identify various possible predictors of EID in stable normoxemic patients of COPD. Materials and Methods: Sixty patients with stable COPD diagnosed and staged as per the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underwent 6MWT. A drop in standard pulse oximetry (SpO 2 ) of ≥4% or nadir up to ≤88% was defined as EID. Based on EID during 6MWT, two groups were formed: desaturators (DS) and nondesaturators (NDS). DS and NDS were compared for baseline and clinical characters by the Student′s t-test while Pearson and Spearman rho correlation coefficient assessed strength of the association of anthropometric and clinical variables with EID. The predictors of EID were identified by logistic regression and receiver operator curve analysis. Result: Out of 60 patients with stable COPD, 33 patients desaturated on exercise (n = 33/60). DS had significantly lower values of FEV 1 (P < 0.001), FVC (P < 0.01) FEV 1 /FVC (P < 0.01) compared to NDS. EID had significant negative correlation with FEV 1 (r = 0.31, P < 0.01), resting oxygen saturation (r = 0.549, P < 0.001) and 6MWD (r = 0.511, P < 0.001). Resting SpO 2 ≤93% was found to a predictor of EID with a sensitivity and specificity of 83% and 78%, respectively. Interpretation and Conclusion: The 6MWT is a safe and sensitive test to recognize EID in normoxic stable COPD patients. Resting oxygen saturation is a good predictor of EID. |
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| format | Article |
| id | doaj.art-8e1708c576ad469d8dc6caec5b2e63c2 |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-12-13T00:01:20Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-8e1708c576ad469d8dc6caec5b2e63c22022-12-22T00:06:23ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2015-01-0132432032510.4103/0970-2113.159550Exercise-induced desaturation in patients with chronic obstructive pulmonary disease on six-minute walk testArchana Chauhan DograUrmil GuptaMalay SarkarAnita PadamBackground and Objectives: Exercise-induced desaturation (EID) is associated with increased mortality in chronic obstructive pulmonary disease (COPD). However, the relationship of EID with anthropometric and clinical parameters of resting pulmonary function test and six-minute walk test (6MWT) in COPD remains unclear. The study was designed to assess the correlate of EID and to identify various possible predictors of EID in stable normoxemic patients of COPD. Materials and Methods: Sixty patients with stable COPD diagnosed and staged as per the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underwent 6MWT. A drop in standard pulse oximetry (SpO 2 ) of ≥4% or nadir up to ≤88% was defined as EID. Based on EID during 6MWT, two groups were formed: desaturators (DS) and nondesaturators (NDS). DS and NDS were compared for baseline and clinical characters by the Student′s t-test while Pearson and Spearman rho correlation coefficient assessed strength of the association of anthropometric and clinical variables with EID. The predictors of EID were identified by logistic regression and receiver operator curve analysis. Result: Out of 60 patients with stable COPD, 33 patients desaturated on exercise (n = 33/60). DS had significantly lower values of FEV 1 (P < 0.001), FVC (P < 0.01) FEV 1 /FVC (P < 0.01) compared to NDS. EID had significant negative correlation with FEV 1 (r = 0.31, P < 0.01), resting oxygen saturation (r = 0.549, P < 0.001) and 6MWD (r = 0.511, P < 0.001). Resting SpO 2 ≤93% was found to a predictor of EID with a sensitivity and specificity of 83% and 78%, respectively. Interpretation and Conclusion: The 6MWT is a safe and sensitive test to recognize EID in normoxic stable COPD patients. Resting oxygen saturation is a good predictor of EID.http://www.lungindia.com/article.asp?issn=0970-2113;year=2015;volume=32;issue=4;spage=320;epage=325;aulast=DograChronic obstructive pulmonary diseaseexercise-induced desaturationpredictors6-minute walk test |
| spellingShingle | Archana Chauhan Dogra Urmil Gupta Malay Sarkar Anita Padam Exercise-induced desaturation in patients with chronic obstructive pulmonary disease on six-minute walk test Lung India Chronic obstructive pulmonary disease exercise-induced desaturation predictors 6-minute walk test |
| title | Exercise-induced desaturation in patients with chronic obstructive pulmonary disease on six-minute walk test |
| title_full | Exercise-induced desaturation in patients with chronic obstructive pulmonary disease on six-minute walk test |
| title_fullStr | Exercise-induced desaturation in patients with chronic obstructive pulmonary disease on six-minute walk test |
| title_full_unstemmed | Exercise-induced desaturation in patients with chronic obstructive pulmonary disease on six-minute walk test |
| title_short | Exercise-induced desaturation in patients with chronic obstructive pulmonary disease on six-minute walk test |
| title_sort | exercise induced desaturation in patients with chronic obstructive pulmonary disease on six minute walk test |
| topic | Chronic obstructive pulmonary disease exercise-induced desaturation predictors 6-minute walk test |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2015;volume=32;issue=4;spage=320;epage=325;aulast=Dogra |
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