In Vitro-Generated Hypertrophic-Like Adipocytes Displaying <i>PPARG</i> Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo

In Vitro-Generated Hypertrophic-Like Adipocytes Displaying <i>PPARG</i> Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo

Reduced neo-adipogenesis and dysfunctional lipid-overloaded adipocytes are hallmarks of hypertrophic obesity linked to insulin resistance. Identifying molecular features of hypertrophic adipocytes requires appropriate in vitro models. We describe the generation of a model of human hypertrophic-like...

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Bibliographic Details
Main Authors: Marianna Aprile, Simona Cataldi, Caterina Perfetto, Maria Rosaria Ambrosio, Paola Italiani, Rosarita Tatè, Matthias Blüher, Alfredo Ciccodicola, Valerio Costa
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
hypertrophic adipocytes
<i>PPARG</i> isoforms
<i>PPARG</i> splicing
dominant-negative isoform
in vitro adipocytes
adipogenesis
Online Access:https://www.mdpi.com/2073-4409/9/5/1284

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