Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products
Neurodegenerative diseases, characterized by progressive loss in selected areas of the nervous system, are becoming increasingly prevalent worldwide due to an aging population. Despite their diverse clinical manifestations, neurodegenerative diseases are multifactorial disorders with standard featur...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/1/94 |
| _version_ | 1797446835854376960 |
|---|---|
| author | Cristina Angeloni Marco Malaguti Cecilia Prata Michela Freschi Maria Cristina Barbalace Silvana Hrelia |
| author_facet | Cristina Angeloni Marco Malaguti Cecilia Prata Michela Freschi Maria Cristina Barbalace Silvana Hrelia |
| author_sort | Cristina Angeloni |
| collection | DOAJ |
| description | Neurodegenerative diseases, characterized by progressive loss in selected areas of the nervous system, are becoming increasingly prevalent worldwide due to an aging population. Despite their diverse clinical manifestations, neurodegenerative diseases are multifactorial disorders with standard features and mechanisms such as abnormal protein aggregation, mitochondrial dysfunction, oxidative stress and inflammation. As there are no effective treatments to counteract neurodegenerative diseases, increasing interest has been directed to the potential neuroprotective activities of plant-derived compounds found abundantly in food and in agrifood by-products. Food waste has an extremely negative impact on the environment, and recycling is needed to promote their disposal and overcome this problem. Many studies have been carried out to develop green and effective strategies to extract bioactive compounds from food by-products, such as peel, leaves, seeds, bran, kernel, pomace, and oil cake, and to investigate their biological activity. In this review, we focused on the potential neuroprotective activity of agrifood wastes obtained by common products widely produced and consumed in Italy, such as grapes, coffee, tomatoes, olives, chestnuts, onions, apples, and pomegranates. |
| first_indexed | 2024-03-09T13:47:19Z |
| format | Article |
| id | doaj.art-8e17859c2d2e467b9c767fe665e177c7 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:47:19Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-8e17859c2d2e467b9c767fe665e177c72023-11-30T20:58:14ZengMDPI AGAntioxidants2076-39212022-12-011219410.3390/antiox12010094Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-ProductsCristina Angeloni0Marco Malaguti1Cecilia Prata2Michela Freschi3Maria Cristina Barbalace4Silvana Hrelia5Department for Life Quality Studies, Alma Mater Studiorum–University of Bologna, Corso D’Augusto 237, 47921 Rimini, ItalyDepartment for Life Quality Studies, Alma Mater Studiorum–University of Bologna, Corso D’Augusto 237, 47921 Rimini, ItalyDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum–University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment for Life Quality Studies, Alma Mater Studiorum–University of Bologna, Corso D’Augusto 237, 47921 Rimini, ItalyDepartment for Life Quality Studies, Alma Mater Studiorum–University of Bologna, Corso D’Augusto 237, 47921 Rimini, ItalyDepartment for Life Quality Studies, Alma Mater Studiorum–University of Bologna, Corso D’Augusto 237, 47921 Rimini, ItalyNeurodegenerative diseases, characterized by progressive loss in selected areas of the nervous system, are becoming increasingly prevalent worldwide due to an aging population. Despite their diverse clinical manifestations, neurodegenerative diseases are multifactorial disorders with standard features and mechanisms such as abnormal protein aggregation, mitochondrial dysfunction, oxidative stress and inflammation. As there are no effective treatments to counteract neurodegenerative diseases, increasing interest has been directed to the potential neuroprotective activities of plant-derived compounds found abundantly in food and in agrifood by-products. Food waste has an extremely negative impact on the environment, and recycling is needed to promote their disposal and overcome this problem. Many studies have been carried out to develop green and effective strategies to extract bioactive compounds from food by-products, such as peel, leaves, seeds, bran, kernel, pomace, and oil cake, and to investigate their biological activity. In this review, we focused on the potential neuroprotective activity of agrifood wastes obtained by common products widely produced and consumed in Italy, such as grapes, coffee, tomatoes, olives, chestnuts, onions, apples, and pomegranates.https://www.mdpi.com/2076-3921/12/1/94agrifood by-productsgrapecoffeetomatoolivechestnut |
| spellingShingle | Cristina Angeloni Marco Malaguti Cecilia Prata Michela Freschi Maria Cristina Barbalace Silvana Hrelia Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products Antioxidants agrifood by-products grape coffee tomato olive chestnut |
| title | Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products |
| title_full | Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products |
| title_fullStr | Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products |
| title_full_unstemmed | Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products |
| title_short | Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products |
| title_sort | mechanisms underlying neurodegenerative disorders and potential neuroprotective activity of agrifood by products |
| topic | agrifood by-products grape coffee tomato olive chestnut |
| url | https://www.mdpi.com/2076-3921/12/1/94 |
| work_keys_str_mv | AT cristinaangeloni mechanismsunderlyingneurodegenerativedisordersandpotentialneuroprotectiveactivityofagrifoodbyproducts AT marcomalaguti mechanismsunderlyingneurodegenerativedisordersandpotentialneuroprotectiveactivityofagrifoodbyproducts AT ceciliaprata mechanismsunderlyingneurodegenerativedisordersandpotentialneuroprotectiveactivityofagrifoodbyproducts AT michelafreschi mechanismsunderlyingneurodegenerativedisordersandpotentialneuroprotectiveactivityofagrifoodbyproducts AT mariacristinabarbalace mechanismsunderlyingneurodegenerativedisordersandpotentialneuroprotectiveactivityofagrifoodbyproducts AT silvanahrelia mechanismsunderlyingneurodegenerativedisordersandpotentialneuroprotectiveactivityofagrifoodbyproducts |