Glomerular changes in trisomy 18-related horseshoe kidney: report of a case and review of the literature
A case of horseshoe kidney is reported in a 11 week-old fetus affected by trisomy 18. Macroscopic examination did not show any other pathological change. The histological picture of the fused-kidney was characterized by architectural and glomerular changes. At x 100 magnification, large areas of met...
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| Format: | Article |
| Language: | English |
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Hygeia Press di Corridori Marinella
2012-10-01
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| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
| Subjects: | |
| Online Access: | https://www.jpnim.com/index.php/jpnim/article/view/10 |
| _version_ | 1818500772693803008 |
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| author | Giuseppina Parodo Clara Gerosa Daniela Fanni Giovanni Ottonello Valerio Mais Peter Van Eyken Nicoletta Iacovidou Gavino Faa |
| author_facet | Giuseppina Parodo Clara Gerosa Daniela Fanni Giovanni Ottonello Valerio Mais Peter Van Eyken Nicoletta Iacovidou Gavino Faa |
| author_sort | Giuseppina Parodo |
| collection | DOAJ |
| description | A case of horseshoe kidney is reported in a 11 week-old fetus affected by trisomy 18. Macroscopic examination did not show any other pathological change. The histological picture of the fused-kidney was characterized by architectural and glomerular changes. At x 100 magnification, large areas of metanephric mesenchyme, characterized by spindle cells surrounded by a loose oedematous stroma, were detected in the deep cortex and in the medulla. At higher power, multiple glomerular changes were observed. Maldeveloped glomeruli showed enlarged capsular spaces, adhesions between vascular tuft and capsular cells, podocytes in multiple layers, and large glomerular bodies formed by two vascular tufts. Our data confirm previous reports on glomerular changes in horseshoe kidney, and reinforce the hypothesis that horseshoe kidney should not be considered a simple fusion problem, but a complex developmental abnormality, possibly involving glomerular development. |
| first_indexed | 2024-12-10T20:47:18Z |
| format | Article |
| id | doaj.art-8e185a38b5ff4b75bf815ccb3d7dafd6 |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-12-10T20:47:18Z |
| publishDate | 2012-10-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-8e185a38b5ff4b75bf815ccb3d7dafd62022-12-22T01:34:11ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922012-10-011110711010.7363/0101047Glomerular changes in trisomy 18-related horseshoe kidney: report of a case and review of the literatureGiuseppina Parodo0Clara Gerosa1Daniela Fanni2Giovanni Ottonello3Valerio Mais4Peter Van Eyken5Nicoletta Iacovidou6Gavino Faa7Division of Pathology, Department of Surgical Sciences, University of Cagliari, CagliariDivision of Pathology, Department of Surgical Sciences, University of Cagliari, CagliariDivision of Pathology, Department of Surgical Sciences, University of Cagliari, CagliariNeonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, AOU University of Cagliari, CagliariDivision of Obstetrics and Gynaecology, Department of Surgical Sciences, University of Cagliari, CagliariDepartment of Pathology, KU Leuven, Leuven2nd Department of Obstetrics and Gynaecology, Aretaieion Hospital, National and Kapodistrian University of AthensDivision of Pathology, Department of Surgical Sciences, University of Cagliari, CagliariA case of horseshoe kidney is reported in a 11 week-old fetus affected by trisomy 18. Macroscopic examination did not show any other pathological change. The histological picture of the fused-kidney was characterized by architectural and glomerular changes. At x 100 magnification, large areas of metanephric mesenchyme, characterized by spindle cells surrounded by a loose oedematous stroma, were detected in the deep cortex and in the medulla. At higher power, multiple glomerular changes were observed. Maldeveloped glomeruli showed enlarged capsular spaces, adhesions between vascular tuft and capsular cells, podocytes in multiple layers, and large glomerular bodies formed by two vascular tufts. Our data confirm previous reports on glomerular changes in horseshoe kidney, and reinforce the hypothesis that horseshoe kidney should not be considered a simple fusion problem, but a complex developmental abnormality, possibly involving glomerular development.https://www.jpnim.com/index.php/jpnim/article/view/10horseshoe kidneytrisomy 18glomerulusclinical casereview |
| spellingShingle | Giuseppina Parodo Clara Gerosa Daniela Fanni Giovanni Ottonello Valerio Mais Peter Van Eyken Nicoletta Iacovidou Gavino Faa Glomerular changes in trisomy 18-related horseshoe kidney: report of a case and review of the literature Journal of Pediatric and Neonatal Individualized Medicine horseshoe kidney trisomy 18 glomerulus clinical case review |
| title | Glomerular changes in trisomy 18-related horseshoe kidney: report of a case and review of the literature |
| title_full | Glomerular changes in trisomy 18-related horseshoe kidney: report of a case and review of the literature |
| title_fullStr | Glomerular changes in trisomy 18-related horseshoe kidney: report of a case and review of the literature |
| title_full_unstemmed | Glomerular changes in trisomy 18-related horseshoe kidney: report of a case and review of the literature |
| title_short | Glomerular changes in trisomy 18-related horseshoe kidney: report of a case and review of the literature |
| title_sort | glomerular changes in trisomy 18 related horseshoe kidney report of a case and review of the literature |
| topic | horseshoe kidney trisomy 18 glomerulus clinical case review |
| url | https://www.jpnim.com/index.php/jpnim/article/view/10 |
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