Long non‐coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2‐mediated epigenetic modification

Long non‐coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2‐mediated epigenetic modification

Abstract Gemcitabine resistance (GR) in pancreatic cancer (PC) results in poor patient outcomes. SMAD family member (Smad4) dysregulation is a significant role of GR in PC, and EZH2 is involved in Smad4 expression in tumor progression. Interestingly, lncRNA small nucleolar RNA host gene 16 (SNHG16)...

Full description

Bibliographic Details
Main Authors: Yi Yu, Yu‐Feng Zou, Run‐Qi Hong, Wen‐Jie Chen, Liang Chen, Wen‐Qi Chen, Hui‐Peng Wang, Yuan Yu
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
EZH2
gemcitabine resistance
lncRNA SNHG16
pancreatic cancer
Smad4
Online Access:https://doi.org/10.1002/kjm2.12574

Similar Items

Similar Items