Epileptic Activity in a Patient with Serum Anti-GAD Antibody-positive Limbic Encephalitis

Limbic encephalopathy (LE) is an entity, which may present with memory loss, seizure, psychiatric symptoms and is usually accompanied by neuro-radiology imaging findings. In recent years, antibody tests that can be studied in detail have gained importance as markers. Glutamic acid decarboxylase anti...

Full description

Bibliographic Details
Main Authors: Zeynep ÖZÖZEN AYAS, Dilcan KOTAN
Format: Article
Language:English
Published: Galenos Yayinevi 2020-04-01
Series:Archives of Epilepsy
Subjects:
Online Access: http://archepilepsy.org/archives/archive-detail/article-preview/epileptic-activity-in-a-patient-with-serum-anti-ga/54790
Description
Summary:Limbic encephalopathy (LE) is an entity, which may present with memory loss, seizure, psychiatric symptoms and is usually accompanied by neuro-radiology imaging findings. In recent years, antibody tests that can be studied in detail have gained importance as markers. Glutamic acid decarboxylase antibody (GAD-Ab) has been reported to be mainly responsible for non-paraneoplastic syndromes. GAD-Ab positivity is predominantly seen in young adult females and temporal lobe epilepsy. Patients with GAD-Ab positive have been reported to respond well or partial to immunotherapy. In this article, we report a 38-year-old woman presenting with seizure and diagnosed with limbic encephalitis who had magnetic resonance imaging and electroencephalograhy findings accompanied by serum GAD-ab positivity was reported. GADAb is considered to play an important role in the prognosis of LE and the other neurological syndromes and should be investigated further.
ISSN:2792-0550