Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations

Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations

Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and multidomain tertiary organization of human PKGIα in active and inactive...

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Bibliographic Details
Main Authors: Arooma Maryam, Rana Rehan Khalid, Sundeep Chaitanya Vedithi, Abdulilah ECE, Suleyman Selim Çınaroğlu, Abdul Rauf Siddiqi, Tom L. Blundell
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Cyclic guanosine monophosphate (cGMP)
Protein kinase Iα (PKGIα)
Auto-inhibitory domain (AI)
Cyclic Nucleotide binding domain-A (CNB-A)
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020303056

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