Identification and toxicity profiling of degradation impurities of riociguat using tandem mass spectrometry and in-silico studies

Identification and toxicity profiling of degradation impurities of riociguat using tandem mass spectrometry and in-silico studies

In the current scenario, the safety aspect related to impurities and their permissible level in the formulation has gained worldwide importance. The ICH (International Conference on Harmonization) guidelines and the official books have addressed this issue critically as it has tremendous regulatory...

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Bibliographic Details
Main Authors: Rahul S Chodankar, Anand A. Mahajan
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Journal of Chromatography Open
Subjects:
Riociguat
Stress studies
HPLC
In-silico toxicity
LC-QTOF
Online Access:http://www.sciencedirect.com/science/article/pii/S2772391722000287

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