Valutazione di alcuni parametri di epatotossicità di nevirapina ed efavirenz su oltre 700 pazienti trattati per infezione da HIV. Assenza di connessioni con il sesso femminile ed una conta di linfociti CD4+ elevata

Valutazione di alcuni parametri di epatotossicità di nevirapina ed efavirenz su oltre 700 pazienti trattati per infezione da HIV. Assenza di connessioni con il sesso femminile ed una conta di linfociti CD4+ elevata

Despite some recent reports which claimed the hypothesis of an increased hepatotoxicity of the antiretroviral drug nevirapine in female patients with a CD4+ lymphocyte count above 250 cells/μL (especially pregnant women), in our open-label comparison of 742 patients treated for the first time with e...

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Bibliographic Details
Main Authors: Roberto Manfredi, Leonardo Calza
Format: Article
Language:English
Published: PAGEPress Publications 2007-03-01
Series:Microbiologia Medica
Subjects:
Hepatotoxicity, nevirapine, efavirenz, gender, CD4+ T-lymphocyte count, baseline laboratory values, naïve patients, pre-treated subjects, salvage antiretroviral therapy
Online Access:http://www.pagepressjournals.org/index.php/mm/article/view/2897
Description
Summary:Despite some recent reports which claimed the hypothesis of an increased hepatotoxicity of the antiretroviral drug nevirapine in female patients with a CD4+ lymphocyte count above 250 cells/μL (especially pregnant women), in our open-label comparison of 742 patients treated for the first time with either a nevirapine or an efavirenz-based HAART as completely naïve patients, experienced subjects, and patients on salvage antiretroviral therapy, we did not disclose any increased hepatotoxicity in nevirapine-treated subjects, in particular with regard to both gender (females versus males), and HIV-related immune deficiency (as represented by a CD4+ count above versus below 250 cells/μL).
ISSN:2280-6423

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