Effect of High Myopia and Cataract Surgery on the Correlation Between Diabetic Retinopathy and Chronic Kidney Disease
PurposeTo investigate the effect of high myopia and cataract surgery on the grading of diabetic retinopathy (DR) and their roles in the correlation between DR and chronic kidney disease (CKD).MethodsA total of 1,063 eyes of 1,063 diabetic patients were enrolled. We conducted binary and multiple mult...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.788573/full |
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| author | Huiqian Kong Siwen Zang Yijun Hu Yijun Hu Yijun Hu Zhanjie Lin Zhanjie Lin Baoyi Liu Xiaomin Zeng Yu Xiao Zijing Du Wu Guanrong Yun Ren Yun Ren Ying Fang Yang Xiaohong Honghua Yu |
| author_facet | Huiqian Kong Siwen Zang Yijun Hu Yijun Hu Yijun Hu Zhanjie Lin Zhanjie Lin Baoyi Liu Xiaomin Zeng Yu Xiao Zijing Du Wu Guanrong Yun Ren Yun Ren Ying Fang Yang Xiaohong Honghua Yu |
| author_sort | Huiqian Kong |
| collection | DOAJ |
| description | PurposeTo investigate the effect of high myopia and cataract surgery on the grading of diabetic retinopathy (DR) and their roles in the correlation between DR and chronic kidney disease (CKD).MethodsA total of 1,063 eyes of 1,063 diabetic patients were enrolled. We conducted binary and multiple multivariate regressions to analyze the ocular and systemic risk factors of DR. Based on the presence of myopia and history of cataract surgery, we divided the cases into four subgroups, namely those with high myopia, with the history of cataract surgery, with both conditions, and with neither, then determined the correlation between the stages of DR and CKD in each subgroup.ResultsIn the binary analysis, high myopia was identified as the protective factor for DR odds ratio (OR): 0.312 [95% confidence interval (CI): 0.195–0.500, p < 0.001], whereas cataract surgery was one of the independent risk factors for DR [OR: 2.818 (95% CI: 1.507–5.273), p = 0.001]. With increased stages of DR, high myopia played an increasingly protective role [mild non-proliferative DR (NPDR), OR = 0.461, p = 0.004; moderate NPDR OR = 0.217, p = 0.003; severe NPDR, OR = 0.221, p = 0.008; proliferative DR (PDR), OR = 0.125, p = 0.001], whereas cataract surgery became a stronger risk factor, especially in PDR (mild NPDR, OR = 1.595, p = 0.259; moderate NPDR, OR = 3.955, p = 0.005; severe NPDR, OR = 6.836, p < 0.001; PDR, OR = 9.756, p < 0.001). The correlation between the stages of DR and CKD in the group with neither high myopia nor cataract surgery history was the highest among all subgroups.ConclusionHigh myopia was a protective factor, whereas cataract surgery is a risk factor for DR, and both factors showed stronger effects throughout the (natural disease) grading of DR. The stages of DR and CKD showed a higher correlation after adjustment of the ocular confounding factors. |
| first_indexed | 2024-12-12T14:00:01Z |
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| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T14:00:01Z |
| publishDate | 2022-06-01 |
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| series | Frontiers in Medicine |
| spelling | doaj.art-8e206c3398ca4dd38bf720e0b45d2fd52022-12-22T00:22:23ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-06-01910.3389/fmed.2022.788573788573Effect of High Myopia and Cataract Surgery on the Correlation Between Diabetic Retinopathy and Chronic Kidney DiseaseHuiqian Kong0Siwen Zang1Yijun Hu2Yijun Hu3Yijun Hu4Zhanjie Lin5Zhanjie Lin6Baoyi Liu7Xiaomin Zeng8Yu Xiao9Zijing Du10Wu Guanrong11Yun Ren12Yun Ren13Ying Fang14Yang Xiaohong15Honghua Yu16Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaRefractive Surgery Center, Guangzhou Aier Eye Hospital, Aier Institute of Refractive Surgery, Guangzhou, ChinaAier School of Ophthalmology, Central South University, Changsha, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaGraduate School, Shantou University Medical College, Shantou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaGraduate School, Shantou University Medical College, Shantou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Southern Medical University, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Guangzhou, ChinaPurposeTo investigate the effect of high myopia and cataract surgery on the grading of diabetic retinopathy (DR) and their roles in the correlation between DR and chronic kidney disease (CKD).MethodsA total of 1,063 eyes of 1,063 diabetic patients were enrolled. We conducted binary and multiple multivariate regressions to analyze the ocular and systemic risk factors of DR. Based on the presence of myopia and history of cataract surgery, we divided the cases into four subgroups, namely those with high myopia, with the history of cataract surgery, with both conditions, and with neither, then determined the correlation between the stages of DR and CKD in each subgroup.ResultsIn the binary analysis, high myopia was identified as the protective factor for DR odds ratio (OR): 0.312 [95% confidence interval (CI): 0.195–0.500, p < 0.001], whereas cataract surgery was one of the independent risk factors for DR [OR: 2.818 (95% CI: 1.507–5.273), p = 0.001]. With increased stages of DR, high myopia played an increasingly protective role [mild non-proliferative DR (NPDR), OR = 0.461, p = 0.004; moderate NPDR OR = 0.217, p = 0.003; severe NPDR, OR = 0.221, p = 0.008; proliferative DR (PDR), OR = 0.125, p = 0.001], whereas cataract surgery became a stronger risk factor, especially in PDR (mild NPDR, OR = 1.595, p = 0.259; moderate NPDR, OR = 3.955, p = 0.005; severe NPDR, OR = 6.836, p < 0.001; PDR, OR = 9.756, p < 0.001). The correlation between the stages of DR and CKD in the group with neither high myopia nor cataract surgery history was the highest among all subgroups.ConclusionHigh myopia was a protective factor, whereas cataract surgery is a risk factor for DR, and both factors showed stronger effects throughout the (natural disease) grading of DR. The stages of DR and CKD showed a higher correlation after adjustment of the ocular confounding factors.https://www.frontiersin.org/articles/10.3389/fmed.2022.788573/fulldiabetic retinopathychronic kidney diseasehigh myopiacataract surgeryfundus image |
| spellingShingle | Huiqian Kong Siwen Zang Yijun Hu Yijun Hu Yijun Hu Zhanjie Lin Zhanjie Lin Baoyi Liu Xiaomin Zeng Yu Xiao Zijing Du Wu Guanrong Yun Ren Yun Ren Ying Fang Yang Xiaohong Honghua Yu Effect of High Myopia and Cataract Surgery on the Correlation Between Diabetic Retinopathy and Chronic Kidney Disease Frontiers in Medicine diabetic retinopathy chronic kidney disease high myopia cataract surgery fundus image |
| title | Effect of High Myopia and Cataract Surgery on the Correlation Between Diabetic Retinopathy and Chronic Kidney Disease |
| title_full | Effect of High Myopia and Cataract Surgery on the Correlation Between Diabetic Retinopathy and Chronic Kidney Disease |
| title_fullStr | Effect of High Myopia and Cataract Surgery on the Correlation Between Diabetic Retinopathy and Chronic Kidney Disease |
| title_full_unstemmed | Effect of High Myopia and Cataract Surgery on the Correlation Between Diabetic Retinopathy and Chronic Kidney Disease |
| title_short | Effect of High Myopia and Cataract Surgery on the Correlation Between Diabetic Retinopathy and Chronic Kidney Disease |
| title_sort | effect of high myopia and cataract surgery on the correlation between diabetic retinopathy and chronic kidney disease |
| topic | diabetic retinopathy chronic kidney disease high myopia cataract surgery fundus image |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.788573/full |
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