APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still poorly understood. We previously showed that GABAergic short-term plasticity is impaired in App knock-out (App-/-) animals, but the precise mechanism by which APP regulates GABAergic synaptic transmission...

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Bibliographic Details
Main Authors: Ming Chen, Jinzhao Wang, Jinxiang Jiang, Xingzhi Zheng, Nicholas J Justice, Kun Wang, Xiangqian Ran, Yi Li, Qingwei Huo, Jiajia Zhang, Hongmei Li, Nannan Lu, Ying Wang, Hui Zheng, Cheng Long, Li Yang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
APP
KCC2
hippocampus
GABA reversal potential
IPSC
protein-protein interaction
Online Access:https://elifesciences.org/articles/20142

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