EGFR-induced suppression of HPV E6/E7 is mediated by microRNA-9-5p silencing of BRD4 protein in HPV-positive head and neck squamous cell carcinoma
Abstract EGFR upregulation is an established biomarker of treatment resistance and aggressiveness in head and neck cancers (HNSCC). EGFR-targeted therapies have shown benefits for HPV-negative HNSCC; surprisingly, inhibiting EGFR in HPV-associated HNSCC led to inferior therapeutic outcomes suggestin...
Main Authors: | Danupon Nantajit, Luana Presta, Thomas Sauter, Mahvash Tavassoli |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2022-11-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-022-05269-8 |
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