The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trial
BackgroundMajor depressive disorder (MDD) has emerged as the fifth leading cause of years lived with disability, with a high prevalent, affecting nearly 4% of the global population. While available evidence suggests that intradermal acupuncture may enhance the effectiveness of antidepressants, wheth...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1181947/full |
| _version_ | 1797826848808239104 |
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| author | Xiaoting Wu Xiaoting Wu Mingqi Tu Mingqi Tu Nisang Chen Nisang Chen Jiajia Yang Junyan Jin Junyan Jin Siying Qu Siying Qu Sangsang Xiong Sangsang Xiong Zhijian Cao Maosheng Xu Shuangyi Pei Hantong Hu Yinyan Ge Jianqiao Fang Xiaomei Shao Xiaomei Shao |
| author_facet | Xiaoting Wu Xiaoting Wu Mingqi Tu Mingqi Tu Nisang Chen Nisang Chen Jiajia Yang Junyan Jin Junyan Jin Siying Qu Siying Qu Sangsang Xiong Sangsang Xiong Zhijian Cao Maosheng Xu Shuangyi Pei Hantong Hu Yinyan Ge Jianqiao Fang Xiaomei Shao Xiaomei Shao |
| author_sort | Xiaoting Wu |
| collection | DOAJ |
| description | BackgroundMajor depressive disorder (MDD) has emerged as the fifth leading cause of years lived with disability, with a high prevalent, affecting nearly 4% of the global population. While available evidence suggests that intradermal acupuncture may enhance the effectiveness of antidepressants, whether its efficacy is a specific therapeutic effect or a placebo effect has not been reported. Moreover, the cerebral mechanism of intradermal acupuncture as a superficial acupuncture (usually subcutaneous needling to a depth of 1–2 mm) for MDD remains unclear.MethodsA total of 120 participants with MDD will be enrolled and randomized to the waiting list group, sham intradermal acupuncture group and active intradermal acupuncture group. All 3 groups will receive a 6-week intervention and a 4-week follow-up. The primary outcome will be measured by the Hamilton Depression Rating Scale-17 and the secondary outcome measures will be the Self-Rating depression scale and Pittsburgh sleep quality index. Assessments will be conducted at baseline, 3 weeks, 6 weeks, and during the follow-up period. In addition, 20 eligible participants in each group will be randomly selected to undergo head magnetic resonance imaging before and after the intervention to explore the effects of intradermal acupuncture on brain activity in MDD patients.DiscussionIf the intradermal acupuncture is beneficial, it is promising to be included in the routine treatment of MDD.Clinical Trial RegistrationClinicaltrials.gov, NCT05720637. |
| first_indexed | 2024-04-09T12:38:50Z |
| format | Article |
| id | doaj.art-8e20fb0f456c4d8db7a6ab1a60361ecb |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-09T12:38:50Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-8e20fb0f456c4d8db7a6ab1a60361ecb2023-05-15T04:42:54ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-05-011410.3389/fpsyt.2023.11819471181947The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trialXiaoting Wu0Xiaoting Wu1Mingqi Tu2Mingqi Tu3Nisang Chen4Nisang Chen5Jiajia Yang6Junyan Jin7Junyan Jin8Siying Qu9Siying Qu10Sangsang Xiong11Sangsang Xiong12Zhijian Cao13Maosheng Xu14Shuangyi Pei15Hantong Hu16Yinyan Ge17Jianqiao Fang18Xiaomei Shao19Xiaomei Shao20Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases, The Third Clinical Medical College, Zhejiang Chinese Medical University,, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases, The Third Clinical Medical College, Zhejiang Chinese Medical University,, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases, The Third Clinical Medical College, Zhejiang Chinese Medical University,, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases, The Third Clinical Medical College, Zhejiang Chinese Medical University,, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases, The Third Clinical Medical College, Zhejiang Chinese Medical University,, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases, The Third Clinical Medical College, Zhejiang Chinese Medical University,, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaKey Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases, The Third Clinical Medical College, Zhejiang Chinese Medical University,, Hangzhou, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaBackgroundMajor depressive disorder (MDD) has emerged as the fifth leading cause of years lived with disability, with a high prevalent, affecting nearly 4% of the global population. While available evidence suggests that intradermal acupuncture may enhance the effectiveness of antidepressants, whether its efficacy is a specific therapeutic effect or a placebo effect has not been reported. Moreover, the cerebral mechanism of intradermal acupuncture as a superficial acupuncture (usually subcutaneous needling to a depth of 1–2 mm) for MDD remains unclear.MethodsA total of 120 participants with MDD will be enrolled and randomized to the waiting list group, sham intradermal acupuncture group and active intradermal acupuncture group. All 3 groups will receive a 6-week intervention and a 4-week follow-up. The primary outcome will be measured by the Hamilton Depression Rating Scale-17 and the secondary outcome measures will be the Self-Rating depression scale and Pittsburgh sleep quality index. Assessments will be conducted at baseline, 3 weeks, 6 weeks, and during the follow-up period. In addition, 20 eligible participants in each group will be randomly selected to undergo head magnetic resonance imaging before and after the intervention to explore the effects of intradermal acupuncture on brain activity in MDD patients.DiscussionIf the intradermal acupuncture is beneficial, it is promising to be included in the routine treatment of MDD.Clinical Trial RegistrationClinicaltrials.gov, NCT05720637.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1181947/fullmajor depressive disorderintradermal acupuncturecerebral mechanismmagnetic resonance imagingmagnetic resonance spectroscopyselective serotonin reuptake inhibitors |
| spellingShingle | Xiaoting Wu Xiaoting Wu Mingqi Tu Mingqi Tu Nisang Chen Nisang Chen Jiajia Yang Junyan Jin Junyan Jin Siying Qu Siying Qu Sangsang Xiong Sangsang Xiong Zhijian Cao Maosheng Xu Shuangyi Pei Hantong Hu Yinyan Ge Jianqiao Fang Xiaomei Shao Xiaomei Shao The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trial Frontiers in Psychiatry major depressive disorder intradermal acupuncture cerebral mechanism magnetic resonance imaging magnetic resonance spectroscopy selective serotonin reuptake inhibitors |
| title | The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trial |
| title_full | The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trial |
| title_fullStr | The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trial |
| title_full_unstemmed | The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trial |
| title_short | The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trial |
| title_sort | efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder a study protocol for a randomized controlled trial |
| topic | major depressive disorder intradermal acupuncture cerebral mechanism magnetic resonance imaging magnetic resonance spectroscopy selective serotonin reuptake inhibitors |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1181947/full |
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