Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials
Biopolymers, such as collagens, elastin, silk fibroin, spider silk, fibrin, keratin, and resilin have gained significant interest for their potential biomedical applications due to their biocompatibility, biodegradability, and mechanical properties. This review focuses on the design and integration...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2025.2449703 |
| _version_ | 1826893850431455232 |
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| author | Juthatip Manissorn Jaturong Promsuk Kittikhun Wangkanont Peerapat Thongnuek |
| author_facet | Juthatip Manissorn Jaturong Promsuk Kittikhun Wangkanont Peerapat Thongnuek |
| author_sort | Juthatip Manissorn |
| collection | DOAJ |
| description | Biopolymers, such as collagens, elastin, silk fibroin, spider silk, fibrin, keratin, and resilin have gained significant interest for their potential biomedical applications due to their biocompatibility, biodegradability, and mechanical properties. This review focuses on the design and integration of biomimetic peptides into these biopolymer platforms to control the release of bioactive molecules, thereby enhancing their functionality for drug delivery, tissue engineering, and regenerative medicine. Elastin-like polypeptides (ELPs) and silk fibroin repeats, for example, demonstrate how engineered peptides can mimic natural protein domains to modulate material properties and drug release profiles. Recombinant spider silk proteins, fibrin-binding peptides, collagen-mimetic peptides, and keratin-derived structures similarly illustrate the ability to engineer precise interactions and to design controlled release systems. Additionally, the use of resilin-like peptides showcases the potential for creating highly elastic and resilient biomaterials. This review highlights current achievements and future perspectives in the field, emphasizing the potential of biomimetic peptides to transform biopolymer-based biomedical applications. |
| first_indexed | 2025-02-17T05:00:48Z |
| format | Article |
| id | doaj.art-8e21ca1fc7454675a1f2c21012657dbd |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2025-02-17T05:00:48Z |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-8e21ca1fc7454675a1f2c21012657dbd2025-01-09T10:15:22ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642025-12-0132110.1080/10717544.2025.2449703Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materialsJuthatip Manissorn0Jaturong Promsuk1Kittikhun Wangkanont2Peerapat Thongnuek3Biomedical Materials and Devices for Revolutionary Integrative Systems Engineering (BMD-RISE) Research Unit, Faculty of Engineering, Chulalongkorn University, Bangkok, ThailandCenter of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, ThailandCenter of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, ThailandBiomedical Materials and Devices for Revolutionary Integrative Systems Engineering (BMD-RISE) Research Unit, Faculty of Engineering, Chulalongkorn University, Bangkok, ThailandBiopolymers, such as collagens, elastin, silk fibroin, spider silk, fibrin, keratin, and resilin have gained significant interest for their potential biomedical applications due to their biocompatibility, biodegradability, and mechanical properties. This review focuses on the design and integration of biomimetic peptides into these biopolymer platforms to control the release of bioactive molecules, thereby enhancing their functionality for drug delivery, tissue engineering, and regenerative medicine. Elastin-like polypeptides (ELPs) and silk fibroin repeats, for example, demonstrate how engineered peptides can mimic natural protein domains to modulate material properties and drug release profiles. Recombinant spider silk proteins, fibrin-binding peptides, collagen-mimetic peptides, and keratin-derived structures similarly illustrate the ability to engineer precise interactions and to design controlled release systems. Additionally, the use of resilin-like peptides showcases the potential for creating highly elastic and resilient biomaterials. This review highlights current achievements and future perspectives in the field, emphasizing the potential of biomimetic peptides to transform biopolymer-based biomedical applications.https://www.tandfonline.com/doi/10.1080/10717544.2025.2449703Peptidebioconjugationbiomimeticcollagenelastinsilk fibroin |
| spellingShingle | Juthatip Manissorn Jaturong Promsuk Kittikhun Wangkanont Peerapat Thongnuek Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials Drug Delivery Peptide bioconjugation biomimetic collagen elastin silk fibroin |
| title | Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials |
| title_full | Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials |
| title_fullStr | Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials |
| title_full_unstemmed | Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials |
| title_short | Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials |
| title_sort | biomimetic peptide conjugates as emerging strategies for controlled release from protein based materials |
| topic | Peptide bioconjugation biomimetic collagen elastin silk fibroin |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2025.2449703 |
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