Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders
Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as it can deliver candidate gene sequences in a spatially and temporally controlled manner in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Materials Today Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590049820300734 |
| _version_ | 1811271112946876416 |
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| author | J.K. Venkatesan A. Rey-Rico W. Meng X. Cai F. Pons L. Lebeau V. Migonney H. Madry M. Cucchiarini |
| author_facet | J.K. Venkatesan A. Rey-Rico W. Meng X. Cai F. Pons L. Lebeau V. Migonney H. Madry M. Cucchiarini |
| author_sort | J.K. Venkatesan |
| collection | DOAJ |
| description | Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as it can deliver candidate gene sequences in a spatially and temporally controlled manner in sites of tissue damage over prolonged periods of time that may be required to durably enhance the specific, natural repair mechanisms in vivo in direct, non-invasive procedures that avoid the arduous manipulation and implantation of patient-dependent cells genetically modified in vitro. In the present work, we provide an overview of the most up-to-date approaches and outcomes in experimental, relevant models of such disorders in vivo using biomaterial-guided gene transfer that may be employed in a near future to treat patients during a clinical intervention as a means to achieve an effective, safe, and persistent translational healing of musculoskeletal injuries. |
| first_indexed | 2024-04-12T22:14:20Z |
| format | Article |
| id | doaj.art-8e22ea27366343cca471bb6b35347d7a |
| institution | Directory Open Access Journal |
| issn | 2590-0498 |
| language | English |
| last_indexed | 2024-04-12T22:14:20Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Advances |
| spelling | doaj.art-8e22ea27366343cca471bb6b35347d7a2022-12-22T03:14:37ZengElsevierMaterials Today Advances2590-04982021-03-019100126Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disordersJ.K. Venkatesan0A. Rey-Rico1W. Meng2X. Cai3F. Pons4L. Lebeau5V. Migonney6H. Madry7M. Cucchiarini8Center of Experimental Orthopaedics, Saarland University Medical Center, D-66421, Homburg/Saar, GermanyCell Therapy and Regenerative Medicine Unit, Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, S-15071, A Coruña, SpainCenter of Experimental Orthopaedics, Saarland University Medical Center, D-66421, Homburg/Saar, GermanyCenter of Experimental Orthopaedics, Saarland University Medical Center, D-66421, Homburg/Saar, GermanyLaboratoire de Conception et Application de Molécules Bioactives, Faculty of Pharmacy, UMR 7199 CNRS-University of Strasbourg, F-67401, Illkirch, FranceLaboratoire de Conception et Application de Molécules Bioactives, Faculty of Pharmacy, UMR 7199 CNRS-University of Strasbourg, F-67401, Illkirch, FranceLBPS/CSPBAT UMR CNRS 7244, Université Sorbonne Paris Nord, F-93430, Villetaneuse, FranceCenter of Experimental Orthopaedics, Saarland University Medical Center, D-66421, Homburg/Saar, GermanyCenter of Experimental Orthopaedics, Saarland University Medical Center, D-66421, Homburg/Saar, Germany; Corresponding author.Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as it can deliver candidate gene sequences in a spatially and temporally controlled manner in sites of tissue damage over prolonged periods of time that may be required to durably enhance the specific, natural repair mechanisms in vivo in direct, non-invasive procedures that avoid the arduous manipulation and implantation of patient-dependent cells genetically modified in vitro. In the present work, we provide an overview of the most up-to-date approaches and outcomes in experimental, relevant models of such disorders in vivo using biomaterial-guided gene transfer that may be employed in a near future to treat patients during a clinical intervention as a means to achieve an effective, safe, and persistent translational healing of musculoskeletal injuries.http://www.sciencedirect.com/science/article/pii/S2590049820300734Orthopedic diseasesGenetic transferTissue engineering |
| spellingShingle | J.K. Venkatesan A. Rey-Rico W. Meng X. Cai F. Pons L. Lebeau V. Migonney H. Madry M. Cucchiarini Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders Materials Today Advances Orthopedic diseases Genetic transfer Tissue engineering |
| title | Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders |
| title_full | Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders |
| title_fullStr | Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders |
| title_full_unstemmed | Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders |
| title_short | Biomaterial-assisted gene therapy for translational approaches to treat musculoskeletal disorders |
| title_sort | biomaterial assisted gene therapy for translational approaches to treat musculoskeletal disorders |
| topic | Orthopedic diseases Genetic transfer Tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2590049820300734 |
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