Characterization of spinal microglial activation in a mouse model of imiquimod-induced psoriasis
Although microglia are associated with chronic pain, the role of spinal microglia in the regulation of itch remains unclear. In this study, we characterized spinal microglial activation in a mouse model of imiquimod (IMQ)-induced psoriasis. Hypertrophic (activated) microglia were observed throughout...
Main Authors: | Fumihiro Saika, Yohji Fukazawa, Shiroh Kishioka, Norikazu Kiguchi |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-12-01
|
Series: | Journal of Pharmacological Sciences |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861323000579 |
Similar Items
-
Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice
by: Fumihiro Saika, et al.
Published: (2021-04-01) -
Chemogenetic activation of central gastrin‐releasing peptide‐expressing neurons elicits itch‐related scratching behavior in male and female mice
by: Norikazu Kiguchi, et al.
Published: (2021-05-01) -
Critical role of GRP receptor–expressing neurons in the spinal transmission of imiquimod‐induced psoriatic itch
by: Norikazu Kiguchi, et al.
Published: (2020-09-01) -
Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions
by: Miho Shiratori-Hayashi, et al.
Published: (2020-11-01) -
Semi-intact ex vivo approach to investigate spinal somatosensory circuits
by: Junichi Hachisuka, et al.
Published: (2016-12-01)