Lingonberry juice improves endothelium-dependent vasodilatation of mesenteric arteries in spontaneously hypertensive rats in a long-term intervention
Phenolic compounds of berries, fruits and vegetables affect vascular health. Endothelium-dependent vasodilatation has an important role in blood pressure development by controlling the vascular tone. Endothelial cells produce and release various relaxing and contracting factors, like nitric oxide (N...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464611000521 |
| _version_ | 1818957981699538944 |
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| author | Anne S. Kivimäki Pauliina I. Ehlers Anu M. Turpeinen Heikki Vapaatalo Riitta Korpela |
| author_facet | Anne S. Kivimäki Pauliina I. Ehlers Anu M. Turpeinen Heikki Vapaatalo Riitta Korpela |
| author_sort | Anne S. Kivimäki |
| collection | DOAJ |
| description | Phenolic compounds of berries, fruits and vegetables affect vascular health. Endothelium-dependent vasodilatation has an important role in blood pressure development by controlling the vascular tone. Endothelial cells produce and release various relaxing and contracting factors, like nitric oxide (NO), cyclo-oxygenase (COX)-derived prostanoids and endothelium-derived hyperpolarizing factor (EDHF). The purpose of this study was to investigate whether 8 weeks treatment with Finnish berry juices, cranberry (Vaccinium oxycoccos), lingonberry (Vaccinium vitis-idaea) and blackcurrant (Ribes nigrum) affects blood pressure and vascular function of spontaneously hypertensive rats (SHR). After 8 weeks treatment the mesenteric arteries of the rats were taken for vascular reactivity studies. Lingonberry treatment normalized the impaired endothelium-dependent relaxation seen in the cranberry, blackcurrant and control rats. In the arteries of lingonberry treated rats the relaxation was partly due to NO, but also dependent on EDHF. It can be concluded that long-term lingonberry juice treatment improves endothelium-dependent vasodilatation of SHR. |
| first_indexed | 2024-12-20T11:18:29Z |
| format | Article |
| id | doaj.art-8e23dab1246e40d4baeb156c67888dc7 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T11:18:29Z |
| publishDate | 2011-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8e23dab1246e40d4baeb156c67888dc72022-12-21T19:42:33ZengElsevierJournal of Functional Foods1756-46462011-10-0134267274Lingonberry juice improves endothelium-dependent vasodilatation of mesenteric arteries in spontaneously hypertensive rats in a long-term interventionAnne S. Kivimäki0Pauliina I. Ehlers1Anu M. Turpeinen2Heikki Vapaatalo3Riitta Korpela4Institute of Biomedicine, Pharmacology, P.O. Box 63, 00014 University of Helsinki, Finland; Corresponding author: Tel.: +358 191 25348; mobile: +358 415013771; fax: +358 191 25364.Institute of Biomedicine, Pharmacology, P.O. Box 63, 00014 University of Helsinki, FinlandValio Ltd., R&D, P.O. Box 30, 00039 Valio, FinlandInstitute of Biomedicine, Pharmacology, P.O. Box 63, 00014 University of Helsinki, FinlandInstitute of Biomedicine, Pharmacology, P.O. Box 63, 00014 University of Helsinki, FinlandPhenolic compounds of berries, fruits and vegetables affect vascular health. Endothelium-dependent vasodilatation has an important role in blood pressure development by controlling the vascular tone. Endothelial cells produce and release various relaxing and contracting factors, like nitric oxide (NO), cyclo-oxygenase (COX)-derived prostanoids and endothelium-derived hyperpolarizing factor (EDHF). The purpose of this study was to investigate whether 8 weeks treatment with Finnish berry juices, cranberry (Vaccinium oxycoccos), lingonberry (Vaccinium vitis-idaea) and blackcurrant (Ribes nigrum) affects blood pressure and vascular function of spontaneously hypertensive rats (SHR). After 8 weeks treatment the mesenteric arteries of the rats were taken for vascular reactivity studies. Lingonberry treatment normalized the impaired endothelium-dependent relaxation seen in the cranberry, blackcurrant and control rats. In the arteries of lingonberry treated rats the relaxation was partly due to NO, but also dependent on EDHF. It can be concluded that long-term lingonberry juice treatment improves endothelium-dependent vasodilatation of SHR.http://www.sciencedirect.com/science/article/pii/S1756464611000521LingonberryExperimental hypertensionVasodilatationPolyphenolsNitric oxideEDHF |
| spellingShingle | Anne S. Kivimäki Pauliina I. Ehlers Anu M. Turpeinen Heikki Vapaatalo Riitta Korpela Lingonberry juice improves endothelium-dependent vasodilatation of mesenteric arteries in spontaneously hypertensive rats in a long-term intervention Journal of Functional Foods Lingonberry Experimental hypertension Vasodilatation Polyphenols Nitric oxide EDHF |
| title | Lingonberry juice improves endothelium-dependent vasodilatation of mesenteric arteries in spontaneously hypertensive rats in a long-term intervention |
| title_full | Lingonberry juice improves endothelium-dependent vasodilatation of mesenteric arteries in spontaneously hypertensive rats in a long-term intervention |
| title_fullStr | Lingonberry juice improves endothelium-dependent vasodilatation of mesenteric arteries in spontaneously hypertensive rats in a long-term intervention |
| title_full_unstemmed | Lingonberry juice improves endothelium-dependent vasodilatation of mesenteric arteries in spontaneously hypertensive rats in a long-term intervention |
| title_short | Lingonberry juice improves endothelium-dependent vasodilatation of mesenteric arteries in spontaneously hypertensive rats in a long-term intervention |
| title_sort | lingonberry juice improves endothelium dependent vasodilatation of mesenteric arteries in spontaneously hypertensive rats in a long term intervention |
| topic | Lingonberry Experimental hypertension Vasodilatation Polyphenols Nitric oxide EDHF |
| url | http://www.sciencedirect.com/science/article/pii/S1756464611000521 |
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