Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestry
<p>Abstract</p> <p>Background</p> <p>A recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in <it>CTNNBL1 </it>are associated with obesity and increased fat mass. We analysed the respectiv...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-02-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/10/14 |
| _version_ | 1818370213897306112 |
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| author | Wichmann H-Erich Illig Thomas Heid Iris M Grallert Harald Friedel Susann Müller Timo D Scherag André Greene Brandon Vogel Carla IG Schäfer Helmut Hebebrand Johannes Hinney Anke |
| author_facet | Wichmann H-Erich Illig Thomas Heid Iris M Grallert Harald Friedel Susann Müller Timo D Scherag André Greene Brandon Vogel Carla IG Schäfer Helmut Hebebrand Johannes Hinney Anke |
| author_sort | Wichmann H-Erich |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>A recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in <it>CTNNBL1 </it>are associated with obesity and increased fat mass. We analysed the respective SNPs in data from our previously published GWA for early onset obesity (case-control design), in GWA data from a population-based cohort of adults, and in an independent family-based obesity study. We investigated whether variants in <it>CTNNBL1 </it>(including rs6013029) and in three other genes (<it>SH3PXD2B</it>, <it>SLIT3 </it>and <it>FLJ42133</it>,) were associated with obesity.</p> <p>Methods</p> <p>The GWA studies were carried out using Affymetrix<sup>® </sup>SNP Chips with approximately 500,000 markers each. In the families, SNP rs6013029 was genotyped using the TaqMan<sup>® </sup>allelic discrimination assay. The German case-control GWA included 487 extremely obese children and adolescents and 442 healthy lean individuals. The adult GWA included 1,644 individuals from a German population-based study (KORA). The 775 independent German families consisted of extremely obese children and adolescents and their parents.</p> <p>Results</p> <p>We found no evidence for an association of the reported variants in <it>CTNNBL1 </it>with early onset obesity or increased BMI. Further, in our family-based study we found no evidence for over-transmission of the rs6013029 risk-allele T to obese children. Additionally, we found no evidence for an association of <it>SH3PXD2B</it>, <it>SLIT3 and FLJ42133 </it>variants in our two GWA samples.</p> <p>Conclusion</p> <p>We detected no confirmation of the recent association of variants in <it>CTNNBL1 </it>with obesity in a population of Central European ancestry.</p> |
| first_indexed | 2024-12-13T23:36:10Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-13T23:36:10Z |
| publishDate | 2009-02-01 |
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| series | BMC Medical Genetics |
| spelling | doaj.art-8e24bae71eb44aaaacf9afa8fc903e062022-12-21T23:27:17ZengBMCBMC Medical Genetics1471-23502009-02-011011410.1186/1471-2350-10-14Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestryWichmann H-ErichIllig ThomasHeid Iris MGrallert HaraldFriedel SusannMüller Timo DScherag AndréGreene BrandonVogel Carla IGSchäfer HelmutHebebrand JohannesHinney Anke<p>Abstract</p> <p>Background</p> <p>A recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in <it>CTNNBL1 </it>are associated with obesity and increased fat mass. We analysed the respective SNPs in data from our previously published GWA for early onset obesity (case-control design), in GWA data from a population-based cohort of adults, and in an independent family-based obesity study. We investigated whether variants in <it>CTNNBL1 </it>(including rs6013029) and in three other genes (<it>SH3PXD2B</it>, <it>SLIT3 </it>and <it>FLJ42133</it>,) were associated with obesity.</p> <p>Methods</p> <p>The GWA studies were carried out using Affymetrix<sup>® </sup>SNP Chips with approximately 500,000 markers each. In the families, SNP rs6013029 was genotyped using the TaqMan<sup>® </sup>allelic discrimination assay. The German case-control GWA included 487 extremely obese children and adolescents and 442 healthy lean individuals. The adult GWA included 1,644 individuals from a German population-based study (KORA). The 775 independent German families consisted of extremely obese children and adolescents and their parents.</p> <p>Results</p> <p>We found no evidence for an association of the reported variants in <it>CTNNBL1 </it>with early onset obesity or increased BMI. Further, in our family-based study we found no evidence for over-transmission of the rs6013029 risk-allele T to obese children. Additionally, we found no evidence for an association of <it>SH3PXD2B</it>, <it>SLIT3 and FLJ42133 </it>variants in our two GWA samples.</p> <p>Conclusion</p> <p>We detected no confirmation of the recent association of variants in <it>CTNNBL1 </it>with obesity in a population of Central European ancestry.</p>http://www.biomedcentral.com/1471-2350/10/14 |
| spellingShingle | Wichmann H-Erich Illig Thomas Heid Iris M Grallert Harald Friedel Susann Müller Timo D Scherag André Greene Brandon Vogel Carla IG Schäfer Helmut Hebebrand Johannes Hinney Anke Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestry BMC Medical Genetics |
| title | Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestry |
| title_full | Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestry |
| title_fullStr | Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestry |
| title_full_unstemmed | Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestry |
| title_short | Non-replication of an association of <it>CTNNBL1 </it>polymorphisms and obesity in a population of Central European ancestry |
| title_sort | non replication of an association of it ctnnbl1 it polymorphisms and obesity in a population of central european ancestry |
| url | http://www.biomedcentral.com/1471-2350/10/14 |
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