RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.
NF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003060&type=printable |
| _version_ | 1826799415151558656 |
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| author | Sophie Luco Olivier Delmas Pierre-Olivier Vidalain Frédéric Tangy Robert Weil Hervé Bourhy |
| author_facet | Sophie Luco Olivier Delmas Pierre-Olivier Vidalain Frédéric Tangy Robert Weil Hervé Bourhy |
| author_sort | Sophie Luco |
| collection | DOAJ |
| description | NF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as an intron of the RelA gene. RelAp43 is expressed in all cell lines and tissues tested and exhibits all the properties of a NF-κB protein. Although its sequence does not include a transactivation domain, identifying it as a class I member of the NF-κB family, it is able to potentiate RelA-mediated transactivation and stabilize dimers comprising p50. Furthermore, RelAp43 stimulates the expression of HIAP1, IRF1, and IFN-β - three genes involved in cell immunity against viral infection. It is also targeted by the matrix protein of lyssaviruses, the agents of rabies, resulting in an inhibition of the NF-κB pathway. Taken together, our data provide the description of a novel functional member of the NF-κB family, which plays a key role in the induction of anti-viral innate immune response. |
| first_indexed | 2024-12-14T23:20:31Z |
| format | Article |
| id | doaj.art-8e25f8639f16407db812b249801d6125 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2025-03-17T00:34:43Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-8e25f8639f16407db812b249801d61252025-02-21T05:32:59ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742012-01-01812e100306010.1371/journal.ppat.1003060RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection.Sophie LucoOlivier DelmasPierre-Olivier VidalainFrédéric TangyRobert WeilHervé BourhyNF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as an intron of the RelA gene. RelAp43 is expressed in all cell lines and tissues tested and exhibits all the properties of a NF-κB protein. Although its sequence does not include a transactivation domain, identifying it as a class I member of the NF-κB family, it is able to potentiate RelA-mediated transactivation and stabilize dimers comprising p50. Furthermore, RelAp43 stimulates the expression of HIAP1, IRF1, and IFN-β - three genes involved in cell immunity against viral infection. It is also targeted by the matrix protein of lyssaviruses, the agents of rabies, resulting in an inhibition of the NF-κB pathway. Taken together, our data provide the description of a novel functional member of the NF-κB family, which plays a key role in the induction of anti-viral innate immune response.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003060&type=printable |
| spellingShingle | Sophie Luco Olivier Delmas Pierre-Olivier Vidalain Frédéric Tangy Robert Weil Hervé Bourhy RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection. PLoS Pathogens |
| title | RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection. |
| title_full | RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection. |
| title_fullStr | RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection. |
| title_full_unstemmed | RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection. |
| title_short | RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection. |
| title_sort | relap43 a member of the nf κb family involved in innate immune response against lyssavirus infection |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003060&type=printable |
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