Acute Acquired Demyelinating Polyneuropathy:An Initial Presentation of Diffuse Large B Cell Lymphoma
Neurological signs and symptoms are commonly associated with both Hodgkin’s and non-Hodgkin’s lymphoma and are mostly attributed to either direct lymphomatous involvement of the nervous system, either as a result of extension to the spinal cord or nerves, or due to infiltration by lymphoma cells and...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2013-01-01
|
| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/141/222 |
| _version_ | 1828465366419898368 |
|---|---|
| author | Munira Shabbir-Moosajee Ghulam Rehman Mohyuddin Sara Khan Ayeesha Kamran Kamal |
| author_facet | Munira Shabbir-Moosajee Ghulam Rehman Mohyuddin Sara Khan Ayeesha Kamran Kamal |
| author_sort | Munira Shabbir-Moosajee |
| collection | DOAJ |
| description | Neurological signs and symptoms are commonly associated with both Hodgkin’s and non-Hodgkin’s lymphoma and are mostly attributed to either direct lymphomatous involvement of the nervous system, either as a result of extension to the spinal cord or nerves, or due to infiltration by lymphoma cells and drug toxicity. Guillain-Barre syndrome and its variants have been reported very infrequently in the literature. We present the case of a 70-year-old male admitted to the hospital for evaluation of uncontrolled hypertension. Incidentally, he was noted to have a low platelet count and a leukoerythroblastic picture in the peripheral blood. Two days into admission, he developed bilateral symmetrical ascending paresis consistent with acute acquired demyelinating polyneuropathy, a common variant of Guillain-Barre syndrome. At about the same time he developed worsening cytopenia and was diagnosed with diffuse large B cell lymphoma according to a bone marrow biopsy. The patient was treated with intravenous immunoglobulin for Guillain-Barre syndrome with significant improvement in muscle strength and subsequently treated with chemotherapy for his lymphoma. |
| first_indexed | 2024-12-11T03:31:41Z |
| format | Article |
| id | doaj.art-8e29599dbc484b648689b099aaf210fc |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-12-11T03:31:41Z |
| publishDate | 2013-01-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-8e29599dbc484b648689b099aaf210fc2022-12-22T01:22:22ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872013-01-01413538Acute Acquired Demyelinating Polyneuropathy:An Initial Presentation of Diffuse Large B Cell LymphomaMunira Shabbir-MoosajeeGhulam Rehman MohyuddinSara KhanAyeesha Kamran KamalNeurological signs and symptoms are commonly associated with both Hodgkin’s and non-Hodgkin’s lymphoma and are mostly attributed to either direct lymphomatous involvement of the nervous system, either as a result of extension to the spinal cord or nerves, or due to infiltration by lymphoma cells and drug toxicity. Guillain-Barre syndrome and its variants have been reported very infrequently in the literature. We present the case of a 70-year-old male admitted to the hospital for evaluation of uncontrolled hypertension. Incidentally, he was noted to have a low platelet count and a leukoerythroblastic picture in the peripheral blood. Two days into admission, he developed bilateral symmetrical ascending paresis consistent with acute acquired demyelinating polyneuropathy, a common variant of Guillain-Barre syndrome. At about the same time he developed worsening cytopenia and was diagnosed with diffuse large B cell lymphoma according to a bone marrow biopsy. The patient was treated with intravenous immunoglobulin for Guillain-Barre syndrome with significant improvement in muscle strength and subsequently treated with chemotherapy for his lymphoma.http://mejc.sums.ac.ir/index.php/mejc/article/view/141/222Guillain-Barre syndromeDiffuse large B cell lymphomaInitial presentationIntravenous immunoglobulin |
| spellingShingle | Munira Shabbir-Moosajee Ghulam Rehman Mohyuddin Sara Khan Ayeesha Kamran Kamal Acute Acquired Demyelinating Polyneuropathy:An Initial Presentation of Diffuse Large B Cell Lymphoma Middle East Journal of Cancer Guillain-Barre syndrome Diffuse large B cell lymphoma Initial presentation Intravenous immunoglobulin |
| title | Acute Acquired Demyelinating Polyneuropathy:An Initial Presentation of Diffuse Large B Cell Lymphoma |
| title_full | Acute Acquired Demyelinating Polyneuropathy:An Initial Presentation of Diffuse Large B Cell Lymphoma |
| title_fullStr | Acute Acquired Demyelinating Polyneuropathy:An Initial Presentation of Diffuse Large B Cell Lymphoma |
| title_full_unstemmed | Acute Acquired Demyelinating Polyneuropathy:An Initial Presentation of Diffuse Large B Cell Lymphoma |
| title_short | Acute Acquired Demyelinating Polyneuropathy:An Initial Presentation of Diffuse Large B Cell Lymphoma |
| title_sort | acute acquired demyelinating polyneuropathy an initial presentation of diffuse large b cell lymphoma |
| topic | Guillain-Barre syndrome Diffuse large B cell lymphoma Initial presentation Intravenous immunoglobulin |
| url | http://mejc.sums.ac.ir/index.php/mejc/article/view/141/222 |
| work_keys_str_mv | AT munirashabbirmoosajee acuteacquireddemyelinatingpolyneuropathyaninitialpresentationofdiffuselargebcelllymphoma AT ghulamrehmanmohyuddin acuteacquireddemyelinatingpolyneuropathyaninitialpresentationofdiffuselargebcelllymphoma AT sarakhan acuteacquireddemyelinatingpolyneuropathyaninitialpresentationofdiffuselargebcelllymphoma AT ayeeshakamrankamal acuteacquireddemyelinatingpolyneuropathyaninitialpresentationofdiffuselargebcelllymphoma |